SynthesisNutrients2024
Comparison of Early Enteral Nutrition Versus Early Parenteral Nutrition in Critically Ill Patients: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Comparative effectiveness of non-pharmacological interventions on health-related quality of life in ICU patients: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- Effects of continuous versus intermittent enteral feeding on feeding tolerance in critically ill adults: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Diagnostic accuracy of gastrointestinal ultrasound in predicting enteral feeding intolerance: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Evidence summary for optimal glycemic variability management during enteral nutrition in adult ICU patients with cerebral infarction.Frontiers in nutrition · 2026Pooled it
- Influence of early enteral nutrition on mortality of adult patients with sepsis: a meta-analysis of randomized controlled trials.European journal of medical research · 2025Pooled it
- Exploratory Assessment of the Internal Structure of the Spanish Version of the Persenius Scale for Enteral Nutrition in Intensive Care Units: A Cross-Sectional Psychometric Study.Journal of clinical medicine · 2026Article
- Article
- Exploring the incidence and influencing factors of acute gastrointestinal injury in ICU patients undergoing mechanical ventilation: a retrospective cohort study.BMC research notes · 2026Article
- Composition and influencing factors of malnutrition management costs among gastrointestinal cancer patients with chronic comorbidities.Frontiers in public health · 2026Article
- Development and validation of an interpretable machine learning model for predicting multidrug-resistant infections in ICU patients.Frontiers in cellular and infection microbiology · 2026Article
- Research Progress of Sepsis and Nutrition: A Bibliometric and Visualized Analysis.Journal of inflammation research · 2026Article
- Case Report: Acute complete esophageal obstruction associated with intraesophageal coagulation of RuiNeng enteral nutrition formula.Frontiers in nutrition · 2026Article
- Therapeutic application of feeding strategies in chronic pancreatitis: the potential for jejunal feeding and elemental diet to modulate pancreatic secretion to alleviate painful symptoms.Frontiers in physiology · 2026Review
- Clinical impact of early enteral nutrition support on gastrointestinal function, nutritional status, liver function, and immune function in liver cancer patients.Frontiers in medicine · 2026Article
- Endometrial carcinoma in a patient with post-stroke sequelae: a case report.Frontiers in medicine · 2026Article
- Early enteral nutrition and dynamic metabolic-inflammatory trajectories in sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Muscle preservation during hospitalization: energy balance, protein intake, and habitual physical activity.Current opinion in clinical nutrition and metabolic care · 2025Review
- Impact of Dietitian-Guided Individualized Nutrition (DGIN) on ICU Outcomes in Critically Ill Patients: A Retrospective Cohort Study in Taiwan.Nutrients · 2025Article
- Early enteral nutrition in critically-ill patients.World journal of critical care medicine · 2025Review
- A Microfluidic Approach for Profiling Total Nitrogen Content in Age-Specific Nutritional Formulas Using Microchip Gel Electrophoresis.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNutritional support is crucial in critically ill patients to enhance recovery, reduce infections, and improve outcomes. This meta-analysis compared early enteral nutrition (EEN) and early parenteral nutrition (EPN) to evaluate their efficacy in adult critically ill patients.
methodsA systematic review of 14 studies involving 7618 patients was conducted, including randomized controlled trials, prospective cohorts, and retrospective analyses. The primary outcomes were mortality and infectious complications, while secondary outcomes included intensive care unit length of stay (ICU-LOS), hospital length of stay (H-LOS), mechanical ventilation days, and gastrointestinal (GI) complications.
resultsThe results showed no significant difference in mortality between EEN and EPN (OR 1.03, 95% CI 0.93-1.14). EEN reduced bloodstream infections (OR 0.73, 95% CI 0.57-0.93), ICU-LOS (MD -0.18 days, 95% CI -0.33 to -0.04), and H-LOS (MD -1.15 days, 95% CI -1.38 to -0.93). However, EEN was associated with higher GI complications, such as vomiting and diarrhea (OR 2.25, 95% CI 1.97-2.58), while mechanical ventilation days showed no significant difference.
conclusionsThese findings support prioritizing EEN in critically ill patients with functional gastrointestinal systems to improve infection control and recovery while emphasizing the importance of careful monitoring to mitigate gastrointestinal complications.
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