Evidence map›Paper›PMID 39796283›Full record

ArticleInternational journal of molecular sciences2025

Sea Anemone Kunitz Peptide HCIQ2c1 Reduces Histamine-, Lipopolysaccharide-, and Carrageenan-Induced Inflammation via the Suppression of Pro-Inflammatory Mediators.

Aleksandra N Kvetkina, Anna A Klimovich, Yulia V Deriavko, Evgeniy A Pislyagin, Ekaterina S Menchinskaya, Evgenia P Bystritskaya, Marina P Isaeva, Ekaterina N Lyukmanova, Zakhar O Shenkarev, Dmitriy L Aminin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Peptide-Based Approaches for Pain Relief and Healing in Wounds.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aleksandra N KvetkinaElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-0937-002X
Anna A KlimovichElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.
Yulia V DeriavkoElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.
Evgeniy A PislyaginElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-3558-0821
Ekaterina S MenchinskayaElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.
Evgenia P BystritskayaElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.
Marina P IsaevaElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-2395-0485
Ekaterina N LyukmanovaBiological Department, Shenzhen MSU-BIT University, Shenzhen 518172, China.ORCID 0000-0002-9728-9407
Zakhar O ShenkarevLaboratory of Structural Biology of Ion Channels, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 119997 Moscow, Russia.ORCID 0000-0003-1383-3522
Dmitriy L AmininElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-1073-4994
Elena V LeychenkoElyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia.ORCID 0000-0002-2360-1365

Funding

Russian Science Foundation 22-14-00326
6 · The paper itself

Abstract

Inflammation is a physiological response of the immune system to infectious agents or tissue injury, which involves a cascade of vascular and cellular events and the activation of biochemical pathways depending on the type of harmful agent and the stimulus generated. The Kunitz peptide HCIQ2c1 of sea anemone

Indexed as

Anti-Inflammatory AgentsInflammationInflammation MediatorsSea AnemonesAnimalsCalciumCarrageenanCyclooxygenase 2EdemaHistamineLipopolysaccharidesMacrophagesMaleMiceNitric Oxide Synthase Type IIRAW 264.7 CellsAnti-Inflammatory AgentsCalciumCarrageenanCyclooxygenase 2HistamineInflammation MediatorsLipopolysaccharidesNitric Oxide Synthase Type IIReactive Oxygen SpeciesTumor Necrosis Factor-alphaanti-inflammatory activitycarrageenancytokinesHeteractis magnificahistamineiNOSKunitz peptidelipopolysaccharidereactive oxygen species

Identifiers

PMID39796283
PMCPMC11721031

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.