Evidence map›Paper›PMID 39796256›Full record

ArticleInternational journal of molecular sciences2025

ProBDNF as a Myokine in Skeletal Muscle Injury: Role in Inflammation and Potential for Therapeutic Modulation of p75

Katherine Aby, Ryan Antony, Tao Yang, Frank M Longo, Yifan Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katherine AbyDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA.
Ryan AntonyDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA.
Tao YangDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7698-3440
Frank M LongoDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Yifan LiDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA.

Funding

The role of pro-BDNF/mature-BDNF balance in skeletal muscle inactivity-induced capillary regressionR01HL147105 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI LI, YIFAN · 2019 to 2022
$1.5M
The role of proBDNF-p75NTR signaling in hind limb ischemia.F31HL167480 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI ABY, KATHERINE · 2023 to 2024
$53k
NHLBI NIH HHS F31 HL167480NHLBI NIH HHS R01 HL147105NIH HHS 1R01HL147105-04A1
6 · The paper itself

Abstract

Brain-derived neurotropic factor (BDNF) is expressed by skeletal muscle as a myokine. Our previous work showed that the active precursor, proBDNF, is the predominant form of BDNF expressed in skeletal muscle, and that following skeletal muscle injury, proBDNF levels are significantly increased. However, the function of the muscle-derived proBDNF in injury-induced inflammation has yet to be fully understood. Using a model of tourniquet-induced ischemia-reperfusion (IR) injury of the hindlimb, this study presents, for the first time, strong and novel evidence that following IR injury, proBDNF is released from skeletal muscle into circulation as an endocrine signaling molecule. Further, this study shows that 1 day post-IR injury, the proBDNF receptor, p75

Indexed as

Brain-Derived Neurotrophic FactorInflammationMuscle, SkeletalProtein PrecursorsReceptors, Nerve Growth FactorReperfusion InjuryAnimalsIsoleucineMaleMiceMice, Inbred C57BLMonocytesMorpholinesMyokinesBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorIsoleucineLM11A-31MorpholinesMyokinesProtein PrecursorsReceptors, Nerve Growth Factorinflammationischemia–reperfusionLM11A-31myokinep75NTRproBDNFskeletal muscle injurysplenic monocytes

Identifiers

PMID39796256
PMCPMC11721097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.