Evidence map›Paper›PMID 39796242›Full record

ArticleInternational journal of molecular sciences2025

Asymmetry of Motif Conservation Within Their Homotypic Pairs Distinguishes DNA-Binding Domains of Target Transcription Factors in ChIP-Seq Data.

Victor G Levitsky, Vladimir V Raditsa, Anton V Tsukanov, Aleksey M Mukhin, Igor F Zhimulev, Tatyana I Merkulova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Victor G LevitskyDepartment of System Biology, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.ORCID 0000-0002-4905-3088
Vladimir V RaditsaDepartment of System Biology, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.
Anton V TsukanovDepartment of System Biology, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.ORCID 0000-0002-5174-6609
Aleksey M MukhinDepartment of System Biology, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.ORCID 0000-0002-1102-0934
Igor F ZhimulevInstitute of Molecular and Cellular Biology, Novosibirsk 630090, Russia.
Tatyana I MerkulovaDepartment of System Biology, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.

Funding

Government FWNR-2022-0020
6 · The paper itself

Abstract

Transcription factors (TFs) are the main regulators of eukaryotic gene expression. The cooperative binding of at least two TFs to genomic DNA is a major mechanism of transcription regulation. Massive analysis of the co-occurrence of overrepresented pairs of motifs for different target TFs studied in ChIP-seq experiments can clarify the mechanisms of TF cooperation. We categorized the target TFs from

Indexed as

Chromatin Immunoprecipitation SequencingDNATranscription FactorsAmino Acid MotifsAnimalsArabidopsisBinding SitesConserved SequenceMiceNucleotide MotifsProtein BindingProtein DomainsDNATranscription Factorschromatin immunoprecipitation followed by sequencingclassification of transcription factorsconservation of motifscooperative binding of transcription factorsdirect binding of transcription factorstranscription factor binding site prediction

Identifiers

PMID39796242
PMCPMC11720554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.