Evidence map›Paper›PMID 39796214›Full record

ArticleInternational journal of molecular sciences2025

Differential Inhibition by Cenobamate of Canonical Human Nav1.5 Ion Channels and Several Point Mutants.

Teodor Asvadur Şulea, Sorin Draga, Maria Mernea, Alexandru Dan Corlan, Beatrice Mihaela Radu, Andrei-Jose Petrescu, Bogdan Amuzescu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teodor Asvadur ŞuleaDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest, Romania.ORCID 0000-0002-3600-0518
Sorin DragaBiotehnos SA, Gorunului Str. 3-5, 075100 Otopeni, Romania.
Maria MerneaDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Alexandru Dan CorlanCardiology Research Unit, University and Emergency Hospital of Bucharest, Splaiul Independenței 169, 050098 Bucharest, Romania.ORCID 0000-0002-9670-8729
Beatrice Mihaela RaduDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.ORCID 0000-0003-4421-2163
Andrei-Jose PetrescuDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest, Romania.
Bogdan AmuzescuDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PCE nr 39/2022: PN-III-P4-PCE-2021-1422
6 · The paper itself

Abstract

Cenobamate is a new and highly effective antiseizure compound used for the treatment of adults with focal onset seizures and particularly for epilepsy resistant to other antiepileptic drugs. It acts on multiple targets, as it is a positive allosteric activator of γ-aminobutyric acid type A (GABA

Indexed as

AnticonvulsantsCarbamatesChlorophenolsNAV1.5 Voltage-Gated Sodium ChannelPoint MutationBinding SitesHumansMolecular Docking SimulationTetrazolesAnticonvulsantsCarbamatesCenobamateChlorophenolsNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanTetrazolesbinding free energycardiac voltage-dependent sodium channelcenobamateMM-GBSAMM-PBSAmolecular dockingmolecular dynamicsNav1.5point mutantstructural model

Identifiers

PMID39796214
PMCPMC11720074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.