Evidence map›Paper›PMID 39796192›Full record

ArticleInternational journal of molecular sciences2025

Position-Dependent Effects of AP Sites Within an

Viktoriia Yu Savitskaya, Kirill A Novoselov, Nina G Dolinnaya, Mayya V Monakhova, Viktoriia G Snyga, Evgeniia A Diatlova, Elizaveta S Peskovatskova, Victor M Golyshev, Mariia I Kitaeva, Daria A Eroshenko and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Viktoriia Yu SavitskayaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Kirill A NovoselovDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Nina G DolinnayaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0003-1780-813X
Mayya V MonakhovaA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-2582-6226
Viktoriia G SnygaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Evgeniia A DiatlovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Elizaveta S PeskovatskovaDepartment of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0009-0005-2307-2255
Victor M GolyshevInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-0521-6228
Mariia I KitaevaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Daria A EroshenkoInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Maria I ZverevaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-7432-1574
Dmitry O ZharkovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0001-5013-0194
Elena A KubarevaA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2021-1343Russian Science Foundation 21-14-00161
6 · The paper itself

Abstract

Apurinic/apyrimidinic (AP) sites are endogenous DNA lesions widespread in human cells. Having no nucleobases, they are noncoding and promutagenic. AP site repair is generally initiated through strand incision by AP endonuclease 1 (APE1). Although AP sites' repair in regular B-DNA has been studied extensively, their processing in G-quadruplexes (G4s) has received much less attention. Here, we used the

Indexed as

DNA-(Apurinic or Apyrimidinic Site) LyaseDNA RepairG-QuadruplexesPromoter Regions, GeneticTelomeraseCircular DichroismDNAHumansAPEX1 protein, humanDNADNA-(Apurinic or Apyrimidinic Site) LyaseTelomeraseTERT protein, humanAPE1apurinic/apyrimidinic sitebase excision repairDNA repairgene expressionG-quadruplexhTERT promoter

Identifiers

PMID39796192
PMCPMC11720163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.