Evidence map›Paper›PMID 39796176›Full record

ArticleInternational journal of molecular sciences2025

Regulation of Age-Related Lipid Metabolism in Ovarian Cancer.

Jihua Feng, Clay Douglas Rouse, Lila Taylor, Santiago Garcia, Ethan Nguyen, Isabella Coogan, Olivia Byrd, Andrew Berchuck, Susan K Murphy, Zhiqing Huang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jihua FengDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.
Clay Douglas RouseDivision of Laboratory Animal Resources (DLAR), Duke University School of Medicine, Durham, NC 27701, USA.
Lila TaylorDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.
Santiago GarciaDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.ORCID 0009-0009-6762-7071
Ethan NguyenDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.
Isabella CooganDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.ORCID 0009-0008-4105-1994
Olivia ByrdDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.
Andrew BerchuckDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC 27701, USA.
Susan K MurphyDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.ORCID 0000-0001-8298-7272
Zhiqing HuangDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, 701 West Main Street, Suite 510, Duke, P.O. Box 90534, Durham, NC 27701, USA.

Funding

Role of Age-Related Changes in the Tumor Microenvironment on Ovarian Cancer ProgressionR03AG068685 · NIA · DUKE UNIVERSITY · PI HUANG, ZHIQING · 2021 to 2022
$161k
American Cancer Society-Duke Cancer Institute Pilot Awards Spring 2024NIA NIH HHS R03 AG068685NIH HHS 1R03TW068685-21A1The Charles Hammond Research Fund Department of Obstetrics and Gynecology
6 · The paper itself

Abstract

The mortality rate of ovarian cancer (OC) remains the highest among female gynecological malignancies. Advanced age is the highest risk factor for OC development and progression, yet little is known about the role of the aged tumor microenvironment (TME). We conducted RNA sequencing and lipidomic analysis of young and aged gonadal adipose tissue from rat xenografts before and after OC formation. The rates of tumor formation (

Indexed as

AgingLipid MetabolismOvarian NeoplasmsAdipose TissueAnimalsFemaleGene Expression Regulation, NeoplasticHumansRatsTumor Microenvironmentaging adipose microenvironmentfree fatty acidsomega-5ovarian cancerrat ovarian cancer xenograftsS100a8s100a9tumor microenvironment

Identifiers

PMID39796176
PMCPMC11720209

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.