Evidence map›Paper›PMID 39796148›Full record

ArticleInternational journal of molecular sciences2024

Head-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort.

Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar de Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel and 20 more

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Connecting genomic and proteomic signatures of amyloid burden in the brain.medRxiv : the preprint server for health sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Raquel PuertaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-1191-5893
Amanda CanoAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Pablo García-GonzálezAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Fernando García-GutiérrezAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-1750-8607
Maria CapdevilaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Itziar de RojasAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-2148-381X
Clàudia OlivéAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-9438-5639
Josep Blázquez-FolchAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0009-0007-2903-7404
Oscar Sotolongo-GrauAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Andrea MiguelAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Laura MontrrealAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Pamela Martino-AdamiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0002-1067-1495
Asif KhanJanssen Pharmaceutica NV, a Johnson & Johnson Company, 2340 Beerse, Belgium.
Adelina OrellanaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Yun Ju SungNeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0002-8021-4070
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.ORCID 0000-0003-4084-5027
Natalie MarchantDivision of Psychiatry, University College London, London W1T 7NK, UK.
Jean Charles LambertInserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Université de Lille, F-59000 Lille, France.
Maitée Rosende-RocaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Montserrat AlegretAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-8164-9500
Maria Victoria FernándezAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Marta MarquiéAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Sergi ValeroAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0002-6599-948X
Lluís TárragaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Carlos CruchagaNeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
Alfredo RamírezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0003-4991-763X
Mercè BoadaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.
Bart SmetsJanssen Pharmaceutica NV, a Johnson & Johnson Company, 2340 Beerse, Belgium.
Alfredo Cabrera-SocorroJanssen Pharmaceutica NV, a Johnson & Johnson Company, 2340 Beerse, Belgium.ORCID 0000-0002-9859-1675
Agustín RuizAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya, 08029 Barcelona, Spain.ORCID 0000-0003-2633-2495

Funding

Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets forAlzheimer's DiseaseR01AG074007 · NIA · WASHINGTON UNIVERSITY · PI YunJu Sung · 2024 to 2026
$2.4M
Agency for Innovation and Entrepreneurship (VLAIO) grant PR067/21Biomedical Research Networking Center on Neurodegenerative Diseases CB06/05/2004 and CB18/05/00010CIBERNED employment plan CNV-304-PRF-866EFPIA Innovative Medicines Initiative Joint Undertaking Grant 115975German Research Foundation (DFG) 01EK2102BInstituto de Salud Carlos III FI20/00215Instituto de Salud Carlos III PI17/01474, PI19/00335, PI22/01403 and PI22/00258Joint Program for Neurodegenerative Diseases (JPND) grant AC19/00097 and 01ED2007ANIA NIH HHS R01 AG074007Sara Borrell grant (ISCIII) CD22/00125Spanish Ministry of Science and Innovation, Proyectos de Generación de Conocimiento grants PID2021-122473OA-I00, PID2021-123462OB-I00 and PID2019-106625RB-I00
6 · The paper itself

Abstract

High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan

Indexed as

Alzheimer DiseaseAntibodiesAptamers, NucleotideProteomicsAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedProteomeReproducibility of ResultsAntibodiesAptamers, NucleotideBiomarkersProteomeAlzheimer’s diseasebiomarkerscerebrospinal fluidmild cognitive impairmentOlinkproteomicsSomaScan

Identifiers

PMID39796148
PMCPMC11720409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.