Evidence map›Paper›PMID 39796139›Full record

ArticleInternational journal of molecular sciences2024

Investigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions.

Shanni Li, Yihui Peng, Yang Yu, Hongjun Xu, Zhaojing Yin, Yiyang Du, Mingyang Ma, Zhongyin Ji, Wenwei Qian

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  4. SIRT1: Protean roles at the nexus of health, disease, and therapeutics.Journal of cell communication and signaling · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shanni LiPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Yihui PengCollege of Computer Science and Software Engineering, Shenzhen University, Shenzhen 518060, China.
Yang YuPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Hongjun XuPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Zhaojing YinSchool of Medicine, Tsinghua University, Beijing 100084, China.
Yiyang DuSchool of Medicine, Tsinghua University, Beijing 100084, China.
Mingyang MaPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Zhongyin JiPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Wenwei QianPeking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.

Funding

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-001National Natural Science Foundation of China 81972046National Natural Science Foundation of China 82372410
6 · The paper itself

Abstract

Osteoarthritis (OA), particularly in the knee and hip, poses a significant global health challenge due to limited therapeutic options. To elucidate the molecular mechanisms of OA and identify potential biomarkers and therapeutic targets, we utilized genome-wide association studies (GWAS) and cis-miRNA expression quantitative trait loci (cis-miR-eQTL) datasets to identify miRNAs associated with OA, revealing 16 that were linked to knee OA and 21 to hip OA. Among these, hsa-miR-1303 was significantly upregulated in both knee and hip OA (IVW:

Indexed as

Circulating MicroRNAMicroRNAsOsteoarthritis, HipOsteoarthritis, KneeBiomarkersGene Expression RegulationGenome-Wide Association StudyHumansQuantitative Trait LociSignal TransductionBiomarkersCirculating MicroRNAMicroRNAsbiological mechanismsdrug targetsmendelian randomizationmicroRNAsosteoarthritissignaling pathways

Identifiers

PMID39796139
PMCPMC11720664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.