Evidence map›Paper›PMID 39796076›Full record

ArticleInternational journal of molecular sciences2024

Local Application of Minimally Manipulated Autologous Stromal Vascular Fraction (SVF) Reduces Inflammation and Improves Bilio-Biliary Anastomosis Integrity.

Ilya Klabukov, Garnik Shatveryan, Nikolay Bagmet, Olga Aleshina, Elena Ivanova, Victoria Savina, Ilmira Gilmutdinova, Dmitry Atiakshin, Michael Ignatyuk, Denis Baranovskii and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ilya KlabukovDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036 Obninsk, Russia.ORCID 0000-0002-2888-7999
Garnik ShatveryanPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.
Nikolay BagmetPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.ORCID 0000-0001-8325-4409
Olga AleshinaPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.
Elena IvanovaPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.
Victoria SavinaPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.
Ilmira GilmutdinovaNational Medical Research Center for Rehabilitation and Balneology of the Ministry of Health of the Russian Federation, Novyy Arbat Str. 2, 121099 Moscow, Russia.
Dmitry AtiakshinScientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis, Patrice Lumumba Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.ORCID 0000-0002-8347-4556
Michael IgnatyukScientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis, Patrice Lumumba Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Denis BaranovskiiDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036 Obninsk, Russia.
Peter ShegayDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036 Obninsk, Russia.
Andrey KaprinDepartment of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva st. 4, 249036 Obninsk, Russia.
Ilya EreminPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.
Nikita ChardarovPetrovsky National Research Centre of Surgery, Abrikosovsky per. 2, 119991 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bilio-biliary anastomosis (BBA) is a critical surgical procedure that is performed with the objective of restoring bile duct continuity. This procedure is often required in cases where there has been an injury to the extrahepatic bile ducts or during liver transplantation. Despite advances in surgical techniques, the healing of BBA remains a significant challenge, with complications such as stricture formation and leakage affecting patient outcomes. The stromal vascular fraction (SVF), a heterogeneous cell population derived from adipose tissue, has demonstrated promise in regenerative medicine due to its rich content of stem cells, endothelial progenitor cells, and growth factors. The objective of this study was to evaluate the potential of locally administered autologous SVF to enhance the healing of BBAs. Bilio-biliary anastomosis was performed on a swine model (female Landrace pigs). Six swine were divided into two groups: the treatment group (

Indexed as

Anastomosis, SurgicalBile DuctsInflammationStromal CellsAdipose TissueAnimalsFemaleSwineTransplantation, AutologousWound Healingbile ductbilio-biliary anastomosischolecystectomyregenerative medicinestromal vascular fractionsurgerytissue engineering

Identifiers

PMID39796076
PMCPMC11720677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.