Evidence map›Paper›PMID 39796074›Full record

ReviewInternational journal of molecular sciences2024

An Overview of the Current State of Cell Viability Assessment Methods Using OECD Classification.

Eneko Madorran, Miha Ambrož, Jure Knez, Monika Sobočan

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Development of Wedelia (Current issues in molecular biology · 2026
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  10. An AOP-guidedNAM journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eneko MadorranFaculty of Medicine, Institute of Anatomy, Histology and Embryology, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.ORCID 0000-0001-6524-4119
Miha AmbrožFaculty of Medicine, Institute of Translational and Clinical Research, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
Jure KnezDepartment for Gynaecologic Oncology and Oncology of the Breast, University Division for Gynaecology and Perinatology, Ljubljanska ulica 5, 2000 Maribor, Slovenia.
Monika SobočanFaculty of Medicine, Institute of Translational and Clinical Research, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.ORCID 0000-0003-1384-9487

Funding

Slovenian Research Agency J3-4523
6 · The paper itself

Abstract

Over the past century, numerous methods for assessing cell viability have been developed, and there are many different ways to categorize these methods accordingly. We have chosen to use the Organisation for Economic Co-operation and Development (OECD) classification due to its regulatory importance. The OECD categorizes these methods into four groups: non-invasive cell structure damage, invasive cell structure damage, cell growth, and cellular metabolism. Despite the variety of cell viability methods available, they can all be categorized within these four groups, except for two novel methods based on the cell membrane potential, which we added to the list. Each method operates on different principles and has its own advantages and disadvantages, making it essential for researchers to choose the method that best fits their experimental design. This review aims to assist researchers in making this decision by describing these methods regarding their potential use and providing direct references to the cell viability assessment methods. Additionally, we use the OECD classification to facilitate potential regulatory use and to highlight the need for adding a new category to their list.

Indexed as

Cell SurvivalOrganisation for Economic Co-Operation and DevelopmentAnimalsHumanscell-based methodscell viabilityin vitro toxicologyOECD cell viability classification

Identifiers

PMID39796074
PMCPMC11719996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.