Evidence map›Paper›PMID 39796071›Full record

ReviewInternational journal of molecular sciences2024

Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics.

Lorenzo Ruggieri, Ottavia Amato, Cristina Marrazzo, Manuela Nebuloni, Davide Dalu, Maria Silvia Cona, Anna Gambaro, Eliana Rulli, Nicla La Verde

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Health impacts of micro- and nanoplastics in humans: systematic review of in vivo evidence.Environmental health : a global access science source · 2026
    Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lorenzo RuggieriDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.ORCID 0000-0002-9972-2761
Ottavia AmatoDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.ORCID 0000-0002-3690-8542
Cristina MarrazzoDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.ORCID 0000-0002-6332-0701
Manuela NebuloniPathology Unit, Luigi University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Davide DaluDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Maria Silvia ConaDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Anna GambaroDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Eliana RulliMethodology for Clinical Research Laboratory, Clinical Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.ORCID 0000-0003-1058-4137
Nicla La VerdeDepartment of Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.ORCID 0000-0002-2884-1632

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, awareness regarding micro-nanoplastics' (MNPs) potential effects on human health has progressively increased. Despite a large body of evidence regarding the origin and distribution of MNPs in the environment, their impact on human health remains to be determined. In this context, there is a major need to address their potential carcinogenic risks, since MNPs could hypothetically mediate direct and indirect carcinogenic effects, the latter mediated by particle-linked chemical carcinogens. Currently, evidence in this field is scarce and heterogeneous, but the reported increased incidence of malignant tumors among younger populations, together with the ubiquitous environmental abundance of MNPs, are rising a global concern regarding the possible role of MNPs in the development and progression of cancer. In this review, we provide an overview of the currently available evidence in eco-toxicology, as well as methods for the identification and characterization of environmental MNP particulates and their health-associated risks, with a focus on cancer. In addition, we suggest possible routes for future research in order to unravel the carcinogenetic potential of MNP exposure and to understand prognostic and preventive implications of intratumoral MNPs.

Indexed as

CarcinogensMicroplasticsNeoplasmsAnimalsEnvironmental ExposureHumansCarcinogensMicroplasticscancercancerogenesiscancerogenicitycarcinogeniccarcinogenicityecotoxicologymicroplasticsnanoplasticstumor

Identifiers

PMID39796071
PMCPMC11720132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.