Evidence map›Paper›PMID 39796069›Full record

ArticleInternational journal of molecular sciences2024

Differential Expression of Proteins Involved in Skin Barrier Maintenance and Vitamin D Metabolism in Atopic Dermatitis: A Cross-Sectional, Exploratory Study.

Teresa Grieco, Giovanni Paolino, Elisa Moliterni, Camilla Chello, Alvise Sernicola, Colin Gerard Egan, Mariangela Morelli, Fabrizio Nannipieri, Santina Battaglia, Marina Accoto and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Vitamin D in the Prevention and Treatment of Inflammatory Skin Diseases.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Teresa GriecoDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7855-6621
Giovanni PaolinoUnit of Dermatology and Cosmetology, IRCCS University Vita-Salute San Raffaele, 20132 Milan, Italy.
Elisa MoliterniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Camilla ChelloDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Alvise SernicolaDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1985-0326
Colin Gerard EganCE Medical Writing Srls, 56021 Pisa, Italy.ORCID 0000-0002-6942-7147
Mariangela MorelliFondazione Pisana per la Scienza, 56017 Pisa, Italy.
Fabrizio NannipieriClinical Research, Abiogen Pharma SpA, 56121 Pisa, Italy.
Santina BattagliaClinical Research, Abiogen Pharma SpA, 56121 Pisa, Italy.
Marina AccotoClinical Research, Abiogen Pharma SpA, 56121 Pisa, Italy.
Erika TirottaClinical Research, Abiogen Pharma SpA, 56121 Pisa, Italy.
Silvia TrasciattiGalileo Research Srl, 56019 Pisa, Italy.
Silvano BonarettiGalileo Research Srl, 56019 Pisa, Italy.
Giovanni PellacaniDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Stefano CalvieriDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Funding

Abiogen Pharma S.p.A, Pisa, Italy N/A
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder influenced by proteins involved in skin barrier maintenance and vitamin D metabolism. Using an intra-patient design, this study compared protein expression in intra-lesional (IL) and peri-lesional (PL) skin biopsies from AD patients and examined associations between protein levels, vitamin D status, and clinical features. Forty-four biopsies from twenty-two AD patients were analyzed using antibody microarrays targeting twelve proteins. IL samples had significantly higher total protein levels than PL samples, with a mean difference of 77.7% (

Indexed as

Dermatitis, AtopicSkinVitamin DAdolescentAdultCross-Sectional StudiesFemaleFilaggrin ProteinsHumansMaleMiddle AgedOccludinVitamin D3 24-HydroxylaseYoung AdultFilaggrin ProteinsFLG protein, humanOccludinVitamin DVitamin D3 24-Hydroxylaseatopic dermatitisprotein expressionskin barrier maintenancevitamin D receptor

Identifiers

PMID39796069
PMCPMC11719518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.