Evidence map›Paper›PMID 39796060›Full record

ArticleInternational journal of molecular sciences2024

Detection of Human GPCR Activity in Drosophila S2 Cells Using the Tango System.

Emil Salim, Aki Hori, Kohei Matsubara, Toshiyuki Takano-Shimizu, Andre Rizky Pratomo, Marianne Marianne, Armia Syahputra, Dadang Irfan Husori, Asuka Inoue, Maryam Aisyah Abdullah and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emil SalimFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Osaka 920-1192, Japan.ORCID 0000-0002-4667-6351
Aki HoriFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Osaka 920-1192, Japan.
Kohei MatsubaraKYOTO Drosophila Stock Center, Kyoto Institute of Technology, Saga Ippongi-cho 1, Ukyo-ku, Kyoto 616-8354, Japan.
Toshiyuki Takano-ShimizuKYOTO Drosophila Stock Center, Kyoto Institute of Technology, Saga Ippongi-cho 1, Ukyo-ku, Kyoto 616-8354, Japan.ORCID 0000-0002-7058-1256
Andre Rizky PratomoFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Osaka 920-1192, Japan.
Marianne MarianneDepartment of Pharmacology and Clinical/Community Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.ORCID 0000-0003-4378-8611
Armia SyahputraDepartement of Periodontology, Faculty of Dentistry, Universitas Sumatera Utara, Medan 20155, Indonesia.
Dadang Irfan HusoriDepartment of Pharmacology and Clinical/Community Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.ORCID 0000-0003-0805-4049
Maryam Aisyah AbdullahDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.
Nur Farisya ShamsudinDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.
Kamal RullahDepartment of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia.
Takayuki KuraishiFaculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Osaka 920-1192, Japan.

Funding

Grant for Joint Research Project of The Center for Advanced Insect Research Promotion, Kyoto Institute of Technology (2017-20) to T.K.Japan Science and Technology Agency JPMJFR2063Universitas Sumatera Utara via Talenta Grant 2023 under the scheme of International Research Collaboration 25/UN5.2.3.1/PPM/KP-TALENTA/R/2023
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are essential cell surface proteins involved in transducing extracellular signals into intracellular responses, regulating various physiological processes. This study validated the use of the Tango assay, a sensitive method for detecting GPCR activation, in

Indexed as

Receptors, G-Protein-CoupledAnimalsCell LineDopamineDrosophilaHumansLigandsLuciferasesDopamineLigandsLuciferasesReceptors, G-Protein-CoupleddopamineDrosophila S2 cellshuman DRD4human GPCRsTango system

Identifiers

PMID39796060
PMCPMC11720185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.