Evidence map›Paper›PMID 39796005›Full record

ArticleInternational journal of molecular sciences2024

Cytotoxic ROS-Consuming Mn(III) Synzymes: Structural Influence on Their Mechanism of Action.

Lorenzo Verderi, Niccolò Nova, Valentina Borghesani, Matteo Tegoni, Marco Giannetto, Simone Fortunati, Luca Ronda, Silvana Pinelli, Paola Mozzoni, Maria Nicastro and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synzymes: The Future of Modern Enzyme Engineering.Applied biochemistry and biotechnology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorenzo VerderiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0009-0001-1316-4579
Niccolò NovaDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0009-0004-9514-7685
Valentina BorghesaniDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Matteo TegoniDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0000-0002-9621-0410
Marco GiannettoDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0000-0001-7031-7466
Simone FortunatiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0000-0003-1921-7974
Luca RondaDepartment of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.ORCID 0000-0002-5389-2669
Silvana PinelliDepartment of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.
Paola MozzoniDepartment of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.
Maria NicastroDepartment of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.
Benedetta GhezziDepartment of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.ORCID 0000-0002-8922-2915
Giorgio PelosiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0000-0002-7946-0602
Franco BisceglieDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0000-0001-9165-0356

Funding

Ministero dell'università e della ricerca - D.M. 737/2021 - PNR - PNRR - NextGenerationEU. Project "A Way Towards Artificial Metal-loenzymes: Redesigned Catalysts and Tools to Understand Nanoscale Reactivity".University of Parma Bando di Ateneo 2022 per la ricerca
6 · The paper itself

Abstract

ROS (i.e., reactive oxygen species) scavenging is a key function of various Mn-based enzymes, including superoxide dismutases (SODs) and catalases, which are actively linked to oxidative stress-related diseases. In this study, we synthesized and characterized two novel Mn(III)-based synzymes (i.e., synthetic enzymes), designated

Indexed as

Antineoplastic AgentsManganeseReactive Oxygen SpeciesAnimalsApoptosisCell Line, TumorHumansHydrogen PeroxideOxidation-ReductionOxidative StressAntineoplastic AgentsHydrogen PeroxideManganeseReactive Oxygen SpeciescytotoxicityMn(III) complexesROSsynzymes

Identifiers

PMID39796005
PMCPMC11719908

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.