SynthesisInternational journal of molecular sciences2024
The Role of Cardiac Troponins in Postmortem Diagnosis of Myocardial Ischemia: A Systematic Review.
Synthesis in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Origin and Application of Cardiomyocyte-Derived Small Extracellular Vesicles: A Systematic Review.International journal of medical sciences · 2026Pooled it
- A Forensic Approach to Perioperative Deaths After Non-Cardiac Surgery: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Integrative Proteomic and Transcriptomic Profiling Identifies Candidate Biomarkers for Discriminating Anaphylactic from Cardiac Sudden Death.International journal of molecular sciences · 2026Article
- Post-Mortem Biomarkers in Sudden Cardiac Death: From Classical Biochemistry to Molecular Autopsy and Multi-Omics Forensic Approaches.International journal of molecular sciences · 2026Review
- Ischemic and non-ischemic myocardial injuries at autopsy- an overview for forensic pathologists.International journal of legal medicine · 2025Review
- An immunostaining-based approach for assessing myocardial viability in the infarcted mouse hearts.Frontiers in cardiovascular medicine · 2025Article
- Elevated serum asprosin and ANGPTL8 gene expression as novel biomarkers for the diagnosis and prognosis of acute coronary syndrome.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postmortem diagnosis of myocardial ischemia remains a challenge in forensic pathology, as traditional methods like autopsy and histology may not always provide conclusive results. Cardiac troponins, specifically cTnI and cTnT, are well-established biomarkers for myocardial injury in living patients, but their role in postmortem ischemia diagnosis is still under investigation. This systematic review aims to evaluate the role of troponins in diagnosing myocardial ischemia in postmortem cases, focusing on the diagnostic accuracy, sample types, and the influence of the postmortem interval (PMI). A systematic search on PubMed NCBI was conducted to identify studies published between 2000 and 2024 that evaluated the use of cTnI and cTnT in postmortem myocardial ischemia diagnosis. The studies were assessed for their sample types, methods of troponin quantification, sensitivity, specificity, and the impact of PMI on the stability of troponin levels. The review included 13 studies that utilized various sample types, including serum, femoral blood, and pericardial fluid. cTnT was found to be more reliable than cTnI, particularly in pericardial fluid, with shorter PMIs (typically under 48 h) showing higher sensitivity and specificity for myocardial ischemia. Pericardial fluid provided the most consistent results, followed by serum and femoral blood. Studies also highlighted that longer PMIs negatively affected the reliability of troponin measurements due to postmortem degradation. Cardiac troponins, especially cTnT, are valuable biomarkers for diagnosing myocardial ischemia postmortem, particularly when measured in pericardial fluid and within a short PMI. The use of multimarker strategies and the development of standardized cut-off values are needed to improve the accuracy of troponin measurements in forensic pathology. Future research should focus on standardizing diagnostic thresholds, improving assay sensitivity, and exploring new sample types and imaging techniques to enhance postmortem cardiovascular diagnostics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.