Evidence map›Paper›PMID 39795915›Full record

ArticleInternational journal of molecular sciences2024

Transcriptomic Analysis of HPV-Positive Oesophageal Tissue Reveals Upregulation of Genes Linked to Cell Cycle and DNA Replication.

Muhammad Osama Shafiq, Muharrem Okan Cakir, Ugur Bilge, Yasmin Pasha, G Hossein Ashrafi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad Osama ShafiqSchool of Life Sciences, Pharmacy and Chemistry, Kingston University London, London KT1 2EE, UK.
Muharrem Okan CakirSchool of Life Sciences, Pharmacy and Chemistry, Kingston University London, London KT1 2EE, UK.
Ugur BilgeDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Akdeniz University, Antalya 07050, Turkey.ORCID 0000-0002-5186-1092
Yasmin PashaDepartment of Gastroenterology, Kingston Hospital, Kingston Upon Thames, London KT2 7QB, UK.
G Hossein AshrafiSchool of Life Sciences, Pharmacy and Chemistry, Kingston University London, London KT1 2EE, UK.ORCID 0000-0002-4516-5111

Funding

Kingston Hospital Charity, UK N/ALaurie Todd Foundation, UK N/A
6 · The paper itself

Abstract

Human papillomavirus (HPV) is a prevalent sexually transmitted infection, implicated in various cancers, yet its influence in non-cancerous oesophageal tissue remains unclear. This study aims to investigate the gene expression changes associated with high-risk HPV (HR-HPV) in non-cancerous oesophageal tissue to elucidate potential early oncogenic mechanisms. Using RNA sequencing, we compared transcriptomic profiles of HPV-positive and HPV-negative non-cancerous oesophageal tissues. Differential gene expression analysis revealed significant upregulation of cell cycle and DNA replication pathways in HPV-positive samples, specifically involving key genes such as

Indexed as

Cell CycleDNA ReplicationEsophagusPapillomaviridaePapillomavirus InfectionsTranscriptomeEsophageal NeoplasmsFemaleGene Expression ProfilingHumansMaleUp-Regulationcell cycle dysregulationDNA replicationHPV positive oesophageal tissuehuman papillomavirus (HPV)non-cancerous oesophageal tissuepolymerase chain reaction (PCR)RNA sequencingtranscriptomic profiling

Identifiers

PMID39795915
PMCPMC11720088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.