Evidence map›Paper›PMID 39795868›Full record

ArticleInternational journal of molecular sciences2024

Developing Allosteric Chaperones for

Marta Montpeyo, Natàlia Pérez-Carmona, Elena Cubero, Aida Delgado, Ana Ruano, Jokin Carrillo, Manolo Bellotto, Marta Martinez-Vicente, Ana Maria Garcia-Collazo

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.Protein science : a publication of the Protein Society · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marta MontpeyoNeurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 08035 Barcelona, Spain.
Natàlia Pérez-CarmonaGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.
Elena CuberoGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2239-6670
Aida DelgadoGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-2793-1545
Ana RuanoGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.
Jokin CarrilloGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.
Manolo BellottoGT Gain Therapeutics SA, 6900 Lugano, Switzerland.
Marta Martinez-VicenteNeurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 08035 Barcelona, Spain.ORCID 0000-0001-7053-2625
Ana Maria Garcia-CollazoGain Therapeutics Sucursal en España, Parc Científic de Barcelona, 08028 Barcelona, Spain.ORCID 0009-0004-9582-7429

Funding

Eurostars-2 joint program E! 113321 - CHAPERONEInstituto de Salud Carlos III, EU/Spain PI20/00728Michael J. Fox Foundation & Silverstein Foundation MJFF 16182MINECO (Spain) FPU18/05595
6 · The paper itself

Abstract

Mutations in the

Indexed as

Gaucher DiseaseGlucosylceramidaseMolecular ChaperonesAllosteric RegulationAnimalsBlood-Brain BarrierFibroblastsHumansMolecular Docking SimulationMutationParkinson DiseaseStructure-Activity RelationshipGBA protein, humanGlucosylceramidaseMolecular ChaperonesGaucher diseaseGBA1glucocerebrosidaselysosomal storage diseaselysosomeParkinson’s diseasepharmacological chaperone

Identifiers

PMID39795868
PMCPMC11720699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.