Evidence map›Paper›PMID 39795865›Full record

ArticleInternational journal of molecular sciences2024

Role Assessment of Water-Soluble Pharmaceutical Form of Phosphatidylcholine on the Catalytic Activity of Cytochrome P450 2C9 and 2D6.

Polina I Koroleva, Tatiana V Bulko, Alexey V Kuzikov, Andrei A Gilep, Yulia A Romashova, Elena G Tichonova, Lyubov V Kostrukova, Alexander I Archakov, Victoria V Shumyantseva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Polina I KorolevaInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.ORCID 0000-0003-2802-5747
Tatiana V BulkoInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.
Alexey V KuzikovInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.ORCID 0000-0002-8772-3214
Andrei A GilepInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.ORCID 0000-0002-3621-6482
Yulia A RomashovaInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.
Elena G TichonovaInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.
Lyubov V KostrukovaInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.ORCID 0000-0002-1607-2936
Alexander I ArchakovInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.
Victoria V ShumyantsevaInstitute of Biomedical Chemistry, Pogodinskaya Street, 10, Build 8, 119121 Moscow, Russia.ORCID 0000-0002-1509-7218

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2024-643
6 · The paper itself

Abstract

This study aimed to investigate whether the water-soluble pharmaceutical form of phosphatidylcholine nanoparticles (wPC) stimulated the catalytic activity of CYP enzymes 2C9 and 2D6. We have shown that electroenzymatic CYP2C9 catalysis to nonsteroidal anti-inflammatory drug naproxen as a substrate was enhanced from 100% to 155% in the presence of wPC in media. Electroenzymatic CYP2D6 activity in the presence of the adrenoceptor-blocking agent bisoprolol as a substrate was elevated significantly from 100% to 144% when wPC was added to potassium phosphate buffer solution. These results indicate the ability of wPC in the form of the phospholipid ultra-small nanoparticles to work as a membrane additive and crowding agent to accelerate the electroenzymatic reactions of cytochrome P450.

Indexed as

Cytochrome P-450 CYP2C9Cytochrome P-450 CYP2D6PhosphatidylcholinesCatalysisHumansNanoparticlesNaproxenSolubilityWaterCYP2C9 protein, humanCytochrome P-450 CYP2C9Cytochrome P-450 CYP2D6NaproxenPhosphatidylcholinesWaterbisoprololcytochrome P450 2C9cytochrome P450 2D6electrochemical analysismacromolecular crowdingnaproxenphosphatidylcholine

Identifiers

PMID39795865
PMCPMC11720032

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.