ArticlePolymers2025
Staggered Design of UV-Curable Polymer Microneedle Arrays with Increased Vertical Action Space.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recent studies have identified microneedle (MN) arrays as promising alternatives for transdermal drug delivery. This study investigated the properties of novel staggered MN arrays design featuring two distinct heights of MNs. The staggered MN arrays were precisely fabricated via PμSL light-cured 3D printing technology. The arrays were systematically evaluated for their morphology, fracture force, skin penetration ability, penetration mechanism, and drug delivery capability. The results demonstrated that the staggered MN arrays punctured the skin incrementally, leveraging the benefits of skin deformation during the puncture process. This approach effectively reduced the puncture force needed, achieving a maximum reduction of approximately 80.27% due to variations in the staggered height. Additionally, the staggered design facilitated skin penetration, as confirmed by the results of the rat skin hematoxylin-eosin (H&E) staining experiments. Compared with 3D-printed planar structures and highly uniform MN arrays, the staggered design exhibited enhanced hydrophilicity, as evidenced by a reduction in the contact angle from approximately 93° to 70°. Simulated drug release images of both coated and hollow staggered MNs illustrated the release and delivery capabilities of these structures across various skin layers, and the staggered design expanded the effective area of the MN arrays within the vertical dimension of the skin layers. This study offers both experimental and theoretical foundations for developing MN arrays with three-dimensional structural distributions, thereby facilitating advancements in MN array technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.