ArticleMolecules (Basel, Switzerland)2025
Synthesis, Structure and Biological Activity of 2-Methyl-5-nitro-6-phenylnicotinohydrazide-Based Hydrazones.
Oralgazy A Nurkenov, Anel Z Mendibayeva, Serik D Fazylov, Tulegen M Seilkhanov, Saule K Kabieva, Ardak K Syzdykov, Ilya I Kulakov, Aleksandr V Iashnikov, Alexey S Vasilchenko, Larisa E Alkhimova and 1 more
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Oralgazy A NurkenovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.ORCID 0000-0003-1878-2787 Anel Z MendibayevaInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.ORCID 0000-0001-6123-3340 Serik D FazylovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.ORCID 0000-0002-4240-6450 Tulegen M SeilkhanovLaboratory of Engineering Profile of NMR Spectroscopy, Sh. Ualikhanov Kokshetau University, 76 Abay St., Kokshetau 020000, Kazakhstan.ORCID 0000-0003-0079-4755 Saule K KabievaDepartment of Chemical Technology and Ecology, Karaganda Industrial University, 30 Republic Ave., Temirtau 101400, Kazakhstan.ORCID 0000-0002-4868-5278 Ardak K SyzdykovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.ORCID 0009-0008-9124-7821 Ilya I KulakovSchool of Natural Sciences, University of Tyumen, 15a Perekopskaya St., Tyumen 625003, Russia.ORCID 0009-0000-2141-1923 Aleksandr V IashnikovLaboratory of Antimicrobial Resistance, Institute of Environmental and Agricultural Biology (X-Bio), University of Tyumen, 23 Lenina St., Tyumen 625003, Russia.ORCID 0009-0007-1999-5932 Alexey S VasilchenkoLaboratory of Antimicrobial Resistance, Institute of Environmental and Agricultural Biology (X-Bio), University of Tyumen, 23 Lenina St., Tyumen 625003, Russia.ORCID 0000-0001-9970-4881 Larisa E AlkhimovaSchool of Natural Sciences, University of Tyumen, 15a Perekopskaya St., Tyumen 625003, Russia.ORCID 0000-0001-6571-6526 Ivan V KulakovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, 1 Alikhanov St., Karaganda 100008, Kazakhstan.ORCID 0000-0001-5772-2096 Funding
Ministry of Science and Higher Education of the Republic of Kazakhstan AP14869941
6 · The paper itselfAbstract
The synthetic availability and wide range of biological activity of hydrazides and hydrazones make them attractive subjects for investigation. In this study, we focused on synthesis of 2-methyl-5-nitro-6-phenylnicotinohydrazide-based hydrazones derived from the corresponding substituted aldehydes. The structure of the obtained compounds was studied using NMR spectroscopy and DFT calculations. After repeated recrystallization, all the synthesized compounds remained as mixtures of isomers. As a result of a detailed analysis, we found that the duplication and bifurcation of signals in the
Indexed as
Anti-Bacterial AgentsHydrazinesHydrazonesAntifungal AgentsDensity Functional TheoryFungiMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsModels, MolecularMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsHydrazinesHydrazonesantibacterial activityconformational analysisDFT calculationshydrazideshydrazonesnicotinic acidNMR spectroscopy
Identifiers
PMID39795225
PMCPMC11721005
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