Evidence map›Paper›PMID 39795190›Full record

ReviewMolecules (Basel, Switzerland)2024

The Role and Mechanisms of Antimicrobial Peptides in Overcoming Multidrug-Resistant Bacteria.

Jinhui Yang, Junning Zhang, Zeyu Feng, Yunqi Ma

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Synergistic Action of Antimicrobial Peptides and Antibiotics.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Conjugative delivery of toxin genesJournal of bacteriology · 2025
    Article
  15. Review
  16. Review
  17. Anti-Antibiotics (Basel, Switzerland) · 2025
    Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jinhui YangSchool of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Junning ZhangSchool of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Zeyu FengSchool of Pharmacy, Binzhou Medical University, Yantai 264003, China.
Yunqi MaSchool of Pharmacy, Binzhou Medical University, Yantai 264003, China.ORCID 0009-0006-9798-8060

Funding

Binzhou Medical University BY2021KYQD02
6 · The paper itself

Abstract

Multidrug-resistant (MDR) bacteria are becoming more and more common, which presents a serious threat to world health and could eventually render many of the antibiotics we currently use useless. The research and development of innovative antimicrobial tactics that can defeat these hardy infections are imperative in light of this predicament. Antimicrobial peptides (AMPs), which have attracted a lot of attention due to their distinct modes of action and capacity to elude conventional resistance mechanisms, are among the most promising of these tactics. As a promising substitute for conventional antibiotics, AMPs are a varied class of naturally occurring compounds that target bacteria membranes and disrupt cellular activities to demonstrate broad-spectrum antimicrobial activity. The objective of this study is to present a thorough summary of the current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, and possible synergy with currently used antimicrobial drugs. In addition, we define the review's scope to include the most recent developments in AMP research, emphasizing the innovations' development, optimization, and therapeutic promise. We hope to emphasize the crucial role that AMPs will play in the future of antimicrobial therapy by bringing together recent research and highlighting current issues. We also hope to advocate for AMPs' continued research and development as part of a comprehensive strategy to counteract the growing threat of antibiotic resistance.

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacteriaDrug Resistance, Multiple, BacterialAnimalsBacterial InfectionsHumansAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAMPsantibiotic resistanceantimicrobial drugsclinical trialsMDR bacteriapeptide engineering

Identifiers

PMID39795190
PMCPMC11721820

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.