Evidence map›Paper›PMID 39795153›Full record

ArticleMolecules (Basel, Switzerland)2024

Synthesis and Antiviral Evaluation of 5-(4-Aryl-1,3-butadiyn-1-yl)-uridines and Their Phosphoramidate Pronucleotides.

Evan Saillard, Otmane Bourzikat, Koffi Assa, Vincent Roy, Luigi A Agrofoglio

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evan SaillardInstitute of Organic and Analytical Chemistry (ICOA UMR 7311), CNRS, University of Orleans, F-45067 Orléans, France.ORCID 0009-0002-2511-2044
Otmane BourzikatInstitute of Organic and Analytical Chemistry (ICOA UMR 7311), CNRS, University of Orleans, F-45067 Orléans, France.ORCID 0000-0001-7152-7991
Koffi AssaInstitute of Organic and Analytical Chemistry (ICOA UMR 7311), CNRS, University of Orleans, F-45067 Orléans, France.
Vincent RoyInstitute of Organic and Analytical Chemistry (ICOA UMR 7311), CNRS, University of Orleans, F-45067 Orléans, France.ORCID 0000-0002-2491-6019
Luigi A AgrofoglioInstitute of Organic and Analytical Chemistry (ICOA UMR 7311), CNRS, University of Orleans, F-45067 Orléans, France.ORCID 0000-0002-6083-0810

Funding

AID 2023004_CLASS_EAT1_ Evan-SaillardCNRS GAVOFEDER EX003677, EX011313, 2021-2027-00022860
6 · The paper itself

Abstract

The emergence of RNA viruses driven by global population growth and international trade highlights the urgent need for effective antiviral agents that can inhibit viral replication. Nucleoside analogs, which mimic natural nucleotides, have shown promise in targeting RNA-dependent RNA polymerases (RdRps). Starting from protected 5-iodouridine, we report the synthesis of

Indexed as

AmidesAntiviral AgentsPhosphoric AcidsUridineHumansMicrobial Sensitivity TestsRNA VirusesSARS-CoV-2Virus ReplicationAmidesAntiviral Agentsphosphoramidic acidPhosphoric AcidsUridine5-substituted-uridinesantiviral activityCadiot–Chodkiewicz cross-couplingphosphoramidate pronucleotideribonucleosides

Identifiers

PMID39795153
PMCPMC11722124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.