ArticleMolecules (Basel, Switzerland)2024
Influence of Sulfur Fumigation on Angelicae Dahuricae Radix: Insights from Chemical Profiles, MALDI-MSI and Anti-Inflammatory Activities.
Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Sulfur fumigation of botanical drugs: impact on chemical composition and pharmacological properties, and advances in detection technologies.Frontiers in pharmacology · 2025Review
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8 authors.
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Abstract
backgroundAngelicae Dahuricae Radix (ADR) is used as both a traditional Chinese medicine and a food ingredient in China and East Asian countries. ADR is generally sun-dried post-harvest but is sometimes sulfur-fumigated to prevent decay and rot. Although there are some studies on the effect of sulfur fumigation on ADR, they are not comprehensive.
methodsThis study used HPLC fingerprinting, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), in vitro anti-inflammatory assays, and metabolite analysis in blood based on UPLC-MS/MS to assess the impact of sulfur fumigation on the active ingredients of ADR.
resultsThere were significant decreases in specific coumarins and amino acids, particularly byakangelicol, oxypeucedanin, L-proline, and L-arginine, following sulfur fumigation. Among the 185 metabolites in blood, there were 30 different compounds, and oxypeucedanin was the most obvious component to decrease after sulfur fumigation. ADR showed anti-inflammatory activity regardless of sulfur fumigation. However, the effects on the production of cytokines in LPS-induced RAW264.7 cells were different.
conclusionsChemometric analysis and in vitro anti-inflammatory studies suggested that byakangelicol and oxypeucedanin could serve as potential quality markers for identifying sulfur-fumigated ADR. These findings provide a chemical basis for comprehensive safety and functional evaluations of sulfur-fumigated ADR, supporting further research in this field.
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