Evidence map›Paper›PMID 39795034›Full record

ArticleAnimals : an open access journal from MDPI2025

Changes in Serum Proteins in Cats with Obesity: A Proteomic Approach.

Esmeralda Cañadas-Vidal, Alberto Muñoz-Prieto, Dina Rešetar Maslov, Ivana Rubić, Juan C González-Sánchez, Juan D Garcia-Martinez, José J Ceron, Vladimir Mrljak, Luis Pardo-Marin, Silvia Martinez-Subiela and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. AData in brief · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Esmeralda Cañadas-VidalInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.ORCID 0009-0004-6292-007X
Alberto Muñoz-PrietoInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.ORCID 0000-0001-6865-8712
Dina Rešetar MaslovInternal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-0159-8281
Ivana RubićInternal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Juan C González-SánchezBioQuant, Heidelberg University, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.
Juan D Garcia-MartinezDepartment of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, Calle Campus Universitario, Espinardo, 30100 Murcia, Spain.ORCID 0000-0003-4209-0107
José J CeronInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.
Vladimir MrljakInternal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-0723-7815
Luis Pardo-MarinInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.ORCID 0000-0001-5398-1162
Silvia Martinez-SubielaInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.ORCID 0000-0002-1524-1558
Asta TvarijonaviciuteInterdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo s/n, Espinardo, 30100 Murcia, Spain.ORCID 0000-0002-5323-5001

Funding

Spanish Ministry of Science and Innovation RYC2021-033660-I
6 · The paper itself

Abstract

Obesity is defined as the excessive accumulation of adipose tissue and is currently the most common disease in cats. Similarly to humans, obesity negatively impacts the health and welfare of cats, predisposing them to many other disorders. The objective of this study was to compare the serum proteomes of normal-weight and overweight/obese cats, aiming to gain insights into the physiopathology of feline obesity and potentially identify new biomarkers. For this, serum samples from a total of 20 adult neutered domestic shorthair client-owned cats, ten normal weight and ten overweight/obese, were submitted to tandem mass tags labelling and liquid chromatography-mass spectrometry (LC-MS/MS) analysis. A total of 288 proteins were detected in the serum samples. Out of these, 12 proteins showed statistically significant differences in abundance between control cats and cats with obesity, namely Ig-like domain-containing protein, Alpha-2-HS-glycoprotein, Complement C8 gamma chain, An-tithrombin-III, Serpin family A member 1, Complement factor H, C3-beta-c, Albumin, C4b-binding protein alpha chain, Alpha-1-B glycoprotein, Solute carrier family 12 member 4, and Fibronectin. Overall this report identifies new proteins involved and provides additional knowledge about the physiopathological changes related to feline obesity.

Indexed as

albuminAlpha-2-HS-glycoproteinantithrombinC4b-binding proteincatcomplementIg-like domain-containing proteinSerpin family A member 1

Identifiers

PMID39795034
PMCPMC11718836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.