ArticleAnimals : an open access journal from MDPI2025
Identification and Analysis of Circular RNAs in Mammary Gland from Yaks Between Lactation and Dry Period.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Post-Transcriptional Regulatory Network of Non-Coding RNAs in Yaks: Molecular Mechanisms of Hypoxia Adaptation and Productive Traits.Animals : an open access journal from MDPI · 2026Review
- The Cuproptosis-Associated AL139023.1/miR-139-5p/ELOVL5 ceRNA Axis Regulates Proliferation, Migration, and Cell Cycle in Esophageal Squamous Cell Carcinoma.Cancer management and research · 2026Article
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Authors and funding
8 authors.
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Abstract
Lactation is a complex physiological process regulated by numerous genes and factors. Circular RNA (circRNA), a non-coding RNA, acts as a molecular sponge that sequesters microRNAs (miRNAs) to regulate target gene expression. Although circRNA has been linked to mammary gland lactation, its specific role in yaks remains underexplored. This study employed circular RNA sequencing (circRNA-seq) to examine the differential expression of circRNAs in yak mammary tissues during lactation and the dry period. Additionally, an enrichment analysis of the differentially expressed circRNAs (DECs) was performed. A competing endogenous RNA (ceRNA) network was then constructed to explore the potential of their roles in lactation and mammary gland development. We detected 18,905 circRNAs in yak mammary tissue, among which 302 showed differential expression. The host genes of these DECs were enriched in functions and pathways associated with yak milk synthesis and composition. Through the construction of a ceRNA network and the enrichment analysis of associated mRNAs, this study identified ceRNAs potentially involved in regulating lactation and mammary gland development. In conclusion, circRNAs in yak mammary tissues were identified and analyzed across lactation and dry periods, establishing a ceRNA network related to lactation regulation. These findings provide novel insights into the regulatory mechanisms governing lactation in yaks (
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