Evidence map›Paper›PMID 39794679›Full record

ArticleClinical journal of gastroenterology2025

Localized light chain amyloidosis of the stomach that regressed after eradication of Helicobacter pylori over 15 years of follow-up: a case report and new hypothesis.

Yukihiro Shirota, Yoshimichi Ueda, Katsuaki Sato, Takayoshi Koura, Yasuhito Takeda, Yuji Hodo, Tokio Wakabayashi

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Case of Localized Gastric Amyloidosis With Improvement on Endoscopy After Eradication of Helicobacter pylori.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yukihiro ShirotaDepartment of Gastroenterology, Saiseikai Kanazawa Hospital, Ni-13-6 Akatsuchimachi, Kanazawa, Ishikawa, 920-0353, Japan. shirota@r4.dion.ne.jp.ORCID http://orcid.org/0000-0001-6561-4626
Yoshimichi UedaDepartment of Pathology, Keiju Medical Center, 94, Tomiokamachi, Nanao, Ishikawa, 926-8605, Japan.
Katsuaki SatoDepartment of Diagnostic Pathology, Noto General Hospital, 6-4 Fujihashi-machi, Nanao, Ishikawa, 926-0816, Japan.
Takayoshi KouraKoura Internal Medicine Clinic, 1-59 Unedanaka, Kanazawa, Ishikawa, 920-0343, Japan.
Yasuhito TakedaDepartment of Gastroenterology, Saiseikai Kanazawa Hospital, Ni-13-6 Akatsuchimachi, Kanazawa, Ishikawa, 920-0353, Japan.
Yuji HodoDepartment of Gastroenterology, Saiseikai Kanazawa Hospital, Ni-13-6 Akatsuchimachi, Kanazawa, Ishikawa, 920-0353, Japan.
Tokio WakabayashiDepartment of Gastroenterology, Saiseikai Kanazawa Hospital, Ni-13-6 Akatsuchimachi, Kanazawa, Ishikawa, 920-0353, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localized light chain amyloidosis is considered to be a plasmacytic B-cell lymphoproliferative disorder caused by antigenic induction. A hypothesis has been proposed that antigen-induced local plasmacytic B cells produce amyloidogenic proteins that are processed into amyloid fibrils in giant cells leading to amyloid fibril deposition. However, the inciting antigen exposure or immune response that signals plasmacytic B-cell infiltration, activation, and selection, is unknown. A case of localized light chain amyloidosis of the stomach that gradually regressed endoscopically after Helicobacter pylori eradication is presented. Histologically, plasmacytes decreased markedly and macrophages disappeared after eradication, and they are thought to play important roles in amyloid formation. There have been no reports of localized gastric amyloidosis in which the lesion regressed and few reports showing the relationship between localized gastric amyloidosis and Helicobacter pylori infection that evaluated the changes after eradication. Given the review of the latest findings about localized light chain amyloidosis, in addition to circumstantial evidence from the clinical course of this case, we would like to propose a bold new hypothesis that Helicobacter pylori could be one of the antigens inducing localized light chain amyloidosis of the stomach.

Indexed as

AmyloidosisHelicobacter InfectionsHelicobacter pyloriStomach DiseasesAnti-Bacterial AgentsFollow-Up StudiesHumansAnti-Bacterial AgentsGiant cellsHelicobacter pyloriImmunoglobulinLocalized light chain amyloidosisPlasmacytoma

Identifiers

PMID39794679

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Registered trials

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