Evidence map›Paper›PMID 39794603›Full record

SynthesisEuropean journal of pediatrics2025

Evaluation of cord management strategies in intrauterine growth-restricted infants: a systematic review and meta-analysis.

Mohamed A Aldemerdash, Mohammed Abdellatif, Merna Raafat Roshdy, Asmaa Zakaria, Ahmed Bayoumi, Mohammed Tarek Hasan, Yaser AbuSammour, Ahmed Aldemerdash, Doaa Mashaly, Naema Hamouda

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed A AldemerdashFaculty of Medicine, Sohag University, Sohag, Egypt.ORCID http://orcid.org/0009-0006-0939-7923
Mohammed AbdellatifMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0000-0001-6872-8426
Merna Raafat RoshdyFaculty of Medicine, Sohag University, Sohag, Egypt. merna.roshdy.z@gmail.com.ORCID http://orcid.org/0000-0002-9952-7245
Asmaa ZakariaMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0009-0000-8339-7274
Ahmed BayoumiMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0009-0006-2973-9337
Mohammed Tarek HasanMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0000-0001-5067-7798
Yaser AbuSammourMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0009-0007-1225-1498
Ahmed AldemerdashFaculty of Medicine, Sohag University, Sohag, Egypt.ORCID http://orcid.org/0009-0005-1602-786X
Doaa MashalyMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0009-0009-4178-2874
Naema HamoudaMedical Research Group of Egypt, Negida Academy, Arlington, MA, USA.ORCID http://orcid.org/0000-0002-6413-8880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delayed cord clamping (DCC) has been widely adopted in both term and preterm infants to improve neonatal outcomes by increasing blood volume and supporting oxygenation. However, the optimal cord management for intrauterine growth-restricted (IUGR) infants is unclear. To systematically review and meta-analyze the effects of DCC compared to early cord clamping (ECC) in IUGR infants. We followed the PRISMA guidelines for meta-analysis. Six databases were searched for randomized controlled trials (RCTs) and observational studies comparing DCC and ECC in IUGR infants, focusing on neonatal resuscitation measures, hematological parameters, morbidities, and mortality. The Cochrane Collaboration tool and Newcastle-Ottawa scale were used for RCTs and observational studies, respectively. Eight studies with 1531 participants were included, comprising six RCTs and two observational studies. Serum ferritin at 3 months and initial Hb were significantly higher in the DCC group (MD: 36.16 ng/ml [95% CI: 34.09, 38.24]), (MD: 1.64 gm/dl [95%CI: 0.88, 2.4]) respectively. The risk of polycythemia was higher in the DCC group (RR 1.88, 95% CI [1.27, 2.8]), without an increase in the peak total serum bilirubin or the need for exchange transfusion. Conclusion: DCC may be beneficial and safe in IUGR infants, improving hematological parameters without affecting neonatal morbidity and mortality. Further high-quality, large trials are needed to confirm these findings and assess neurodevelopmental impact.

Indexed as

Fetal Growth RetardationUmbilical Cord ClampingFemaleHumansInfant, NewbornRandomized Controlled Trials as TopicClamping, Umbilical cordDelayed cord clampingImmediate cord clampingIntrauterine growth retardationPlacental transfusionUmbilical cord milking

Identifiers

PMID39794603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.