ArticleEye (London, England)2025
Choriocapillaris flow in two different patterns of exudative type 1 macular neovascularization.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Geometric and concavity characteristics as diagnostic markers for differentiating nAMD-related MNV from pachychoroid neovascularisation.Eye (London, England) · 2026Article
- Choroidal neovascularization as a trigger for central serous chorioretinopathy.International journal of retina and vitreous · 2025Article
- Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration.Ophthalmology and therapy · 2025Article
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Authors and funding
11 authors.
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Abstract
backgroundTo compare the characteristics of type 1 macular neovascularization (MNV) and the surrounding choriocapillaris (CC) perfusion in patients with neovascular age-related macular degeneration (nAMD) versus those with pachychoroid neovasculopathy (PNV) using swept-source optical coherence tomography angiography (SS-OCTA).
methodsThis retrospective study included 64 treatment-naïve eyes (37 nAMD, 27 PNV) with type 1 MNV. SS-OCTA images were analysed to measure MNV area and perimeter, and CC flow deficits (FD) in five concentric rings surrounding the lesion. CC FD percentage (FD%), area (FDa), and number (FDn) were quantified. Intervortex anastomoses presence was also assessed.
resultsMNV lesions in nAMD were significantly larger in area (2.94 vs 1.56 mm², p = 0.013) and perimeter (8.76 vs 5.85 mm, p = 0.004) compared to PNV. PNV eyes showed higher FD% and larger FDa across all rings (p < 0.05), while FDn did not differ significantly. Intervortex anastomoses were more prevalent in PNV (81.5% vs 35.1%, p = 0.0002). In nAMD, MNV size correlated positively with FD% in inner rings and FDn in all rings. In PNV, MNV size correlated only with FDn.
conclusionsDespite smaller MNV lesions, PNV eyes demonstrated more extensive CC flow deficits compared to nAMD. The distinct CC flow patterns and their correlations with MNV characteristics suggest different pathophysiological mechanisms underlying these conditions. These findings may have implications for differential diagnosis and tailored treatment approaches in nAMD and PNV.
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