Evidence map›Paper›PMID 39794534›Full record

ArticleAbdominal radiology (New York)2025

Liver stiffness: a novel imaging biomarker by ultrasound elastography for prediction of early allograft failure following liver transplantation.

Yuchen Yang, Yu Gong, Wen Shen, Yunling Fan, Haohao Yin, Wenping Wang, Huixiong Xu, Yuli Zhu, Hong Han

Abstract read
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuchen YangDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu GongDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Wen ShenDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Yunling FanDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Haohao YinDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenping WangDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Huixiong XuDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuli ZhuDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China. zhu.yuli@zs-hospital.sh.cn.
Hong HanDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China. han.hong@zs-hospital.sh.cn.

Funding

Health Commission Health Sector Clinical Research Special Clinical Project 202340087
6 · The paper itself

Abstract

objectivesThe objective of this study was to evaluate the role of Liver Stiffness Measurement (LSM) and serum transaminase levels for predicting early allograft failure (EAF) after liver transplantation (LT).

methodsA total of 189 patients who underwent LT were prospectively recruited in the study. Of these patients, 13 cases died or received re-transplantation within 90 days after surgery were classified as EAF group, while rest 176 patients were included in the non-EAF group. LSM values and serum transaminase levels within 1 week after operation were recorded and compared between two groups. The area under the curve (AUC) was utilized to assess the performance of LSM, serum transaminase and their combination in predicting EAF.

resultsThe earliest significant difference in LSM between EAF and non-EAF group was observed on postoperative day 3 (POD-3) (p = 0.046). Comparing to non-EAF group, patients in the EAF group had higher aspartate-aminotransferase (AST) and alanine aminotransferase (ALT) on postoperative day 2 (POD-2)(p = 0.009, 0.033), and also demonstrated higher AST on POD-3 (p = 0.021). Furthermore, the reduction rate of AST/ALT from day 1 to day 3 (AST/ALT Red) were slower (p = 0.001, 0.014) in EAF group. Using a LSM value > 12.1 kPa and an AST level > 339U/L on POD-3 predicted EAF with a sensitivity of 89%, a specificity of 86%, and an AUC of 0.926, surpassing the traditional early allograft dysfunction (EAD) model.

conclusionsThe combination of LSM values and AST levels on the third day after LT can effectively predict EAF and facilitate timely interventions.

Indexed as

Elasticity Imaging TechniquesGraft RejectionLiver TransplantationPostoperative ComplicationsAdultAlanine TransaminaseAllograftsAspartate AminotransferasesBiomarkersFemaleHumansLiverMaleMiddle AgedPredictive Value of TestsProspective StudiesAlanine TransaminaseAspartate AminotransferasesBiomarkersEarly allograft failureLiver stiffnessLiver transplantationTransaminases

Identifiers

PMID39794534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.