ArticleScientific reports2025
Comparative measurement of short-term fluoride release and inhibition of caries around restoration by ion releasing restorative materials: an in vitro study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- A two-year randomized clinical trial of bulk-fill and ion-releasing composites with universal adhesives in class V carious lesions.Clinical oral investigations · 2026Trial
- Effect of moisture control on root caries progression adjacent to different restorative materials in an in-vitro biofilm model.Odontology · 2026Article
- The Cariostatic Mechanisms of Fluoride-An Updated Review.Dentistry journal · 2026Review
- Performance of an alkasite restorative material under acidic conditions: surface roughness, gloss and hardness.Scientific reports · 2026Article
- Development of a fast-crosslinking hydrogel system doped with magnetic mesoporous nanoparticles for sustained fluoride ion release and caries prevention.Frontiers in bioengineering and biotechnology · 2026Article
- Antibacterial effects and remineralization potential of silver nanoparticles in a novel nanosilver fluoride formulation.BMC oral health · 2025Article
- Evaluation of fluoride and calcium ion release and fluoride recharge capacity of glass-ionomer materials modified with experimental bioactive glass.Scientific reports · 2025Article
- Comparative Analysis of Flexural and Compressive Strengths of Bioactive Alkasite Compared to Other Ion-Releasing Restorative Materials.Biomimetics (Basel, Switzerland) · 2025Article
- Fluoride Release from Pediatric Dental Restorative Materials: A Laboratory Investigation.Dentistry journal · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main objective of the current study is to compare short-term fluoride release of three ion releasing restorative materials and assess their inhibitory effect on secondary caries. Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14. For assessing secondary caries inhibition, sixty-six sound molar teeth were used and standardized class V cavities were prepared. Teeth were divided into three groups according to each material, followed by 800 cycles of thermocycling. Subsequently, teeth were immersed in a solution containing cariogenic bacteria for 30 days. After that, teeth were sectioned bucco-lingually and analyzed using a polarized light microscope to measure inhibition area, outer lesion depth, and extension. Data was statistically analyzed using different tests. The study results revealed a statistically significant differences in fluoride release existed among materials. Self-adhesive hybrid composite exhibited the highest fluoride release. Lesion extension and depth were statistically significantly greater next to Ion-releasing flowable composite liner. The inhibition areas next to the Self-adhesive hybrid composite were statistically significantly larger than the other two materials. In conclusion, all tested ion-releasing restorative materials displayed fluoride release and the potential to inhibit secondary caries formation. Self-adhesive hybrid composite demonstrated the highest fluoride-releasing potential and the greatest ability to inhibit secondary caries. Conversely, Ion-releasing flowable composite liner exhibited the least fluoride release with minimal secondary caries inhibition. Increasing fluoride release correlated with larger inhibition areas and reduced outer lesion depth and extension.
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Registered trials
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