Evidence map›Paper›PMID 39794339›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study.

Jianmeng Song, Edgardo Carmona-Torres, Yasaman Kambari, Sofia Chavez, Fumihiko Ueno, Teruki Koizum, Aron Amaev, Ali Abdolizadeh, Vincenzo De Luca, Daniel M Blumberger and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jianmeng SongMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-8223-8845
Edgardo Carmona-TorresMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Yasaman KambariMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0696-1692
Sofia ChavezInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Fumihiko UenoMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3463-5672
Teruki KoizumMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Aron AmaevMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Ali AbdolizadehMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0984-4141
Vincenzo De LucaInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Daniel M BlumbergerInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Gary RemingtonInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Bruce PollockInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0802-3998
Ariel Graff-GuerreroMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Philip GerretsenMultimodal Imaging Group, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. philgerretsen@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired insight into illness occurs in up to 98% of patients with schizophrenia, depending on the stage of illness, and leads to negative clinical outcomes. Previous neuroimaging studies suggest that impaired insight in patients with schizophrenia may be related to structural and functional anomalies in frontoparietal brain regions. To date, limited studies have investigated the association between regional cerebral blood flow (CBF) and impaired insight in schizophrenia. Therefore, we sought to investigate the relationship between regional CBF, as measured by arterial spin labeling (ASL), and impaired insight in participants with schizophrenia. A total of 32 participants were included in the analysis. Impaired insight in patients with schizophrenia was measured using the VAGUS, Self-report (VAGUS-SR). Resting-state regional CBF was measured using pseudo-continuous ASL (pCASL) and extracted using SPM12 and REX toolbox. Whole brain analysis found that impaired insight was associated with higher regional CBF in the right angular gyrus, left supramarginal gyrus, and right superior frontal region when controlling for age, gender, smoking status, and illness severity. The results indicate that impaired insight in schizophrenia is related to regional CBF in frontoparietal areas. These neuroimaging findings can serve as therapeutic targets for intervention, such as with non-invasive brain stimulation.

Identifiers

PMID39794339
PMCPMC11723987

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.