Observational studyPsycho-oncology2025
Longitudinal Psychological Distress After Malignant Brain Tumor Diagnosis: A Multilevel Analysis of Patients and Their Caregivers.
Observational study in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of psychological burden in family caregivers of patients with brain tumors.Scientific reports · 2025Pooled it
- Illness Perception and Psychosocial Adjustment in Brain Tumor Patients and Their Family Caregivers: An Actor-Partner Interdependence Model Analysis.Cancer medicine · 2026Article
- Health-related quality-of-life of WHO grade 4 astrocytoma patients receiving alternating electrical field therapy: a prospective real-world multi-centre study.Journal of neuro-oncology · 2026Article
- Prehabilitation for Patients with Brain Tumours: A Single-Centre Retrospective Cohort Study.Current oncology (Toronto, Ont.) · 2026Article
- Platelet-to-high-density lipoprotein cholesterol ratio as a potential mediator in the obesity-chronic kidney disease association among hypertensive patients.Renal failure · 2025Article
- Predicting Caregiver Anxiety and Depression From Patient Distress in Brain Tumor Dyads: Actor-Partner Interdependence Model.Cancer medicine · 2025Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveMalignant brain tumors are associated with debilitating symptoms and a poor prognosis, resulting in high psychological distress for patients and caregivers. There is a lack of longitudinal studies investigating psychological distress in this group. This study evaluated fear of progression (FoP), anxiety and depression in patients and their caregivers in the 6 months following malignant brain tumor diagnosis.
methodsThis prospective, observational study assessed FoP (FoP-Q-SF[P]), anxiety and depression (HADS) at diagnosis (T0) and after three (T1) and 6 months (T2) in patients with malignant brain tumors (primary, secondary) and their caregivers. Multilevel analyses were used to examine changes over time and differences between patients and caregivers, while accounting for the interdependence in their distress values.
resultsSeventy-one patients and 68 caregivers were included in the analysis. Throughout the study period, over 50% reported clinically relevant FoP, almost 50% reported clinically relevant anxiety, and over 30% reported relevant depression. Over all time points, caregivers reported significantly higher anxiety and depression than patients. Anxiety decreased between T0 and T2 in both groups. Exploratory analyses showed that female sex was associated with higher anxiety, and older age with higher depression. No significant predictors were identified for FoP.
conclusionA substantial number of patients and caregivers experience clinically relevant psychological distress in the 6 months following a malignant brain tumor diagnosis. Caregivers are particularly distressed, reporting higher anxiety and depression. Integrating psycho-oncological assessments and interventions for both patients and caregivers into clinical care is critical to address the psychological distress associated with malignant brain tumors.
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