Evidence map›Paper›PMID 39793560›Full record

ArticleCell2025

Direct visualization of electric-field-stimulated ion conduction in a potassium channel.

BoRam Lee, K Ian White, Michael Socolich, Margaret A Klureza, Robert Henning, Vukica Srajer, Rama Ranganathan, Doeke R Hekstra

Abstract read
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. High-Throughput MicroED for Probing Ion Channel Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Review
  13. Effective polarization in potassium channel simulations: Ion conductance, occupancy, voltage response, and selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. SFCalculator: connecting deep generative models and crystallography.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

BoRam LeeCenter for Physics of Evolving Systems, Biochemistry & Molecular Biology and the Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA; Modeling and Informatics, Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA.
K Ian WhiteDepartment of Molecular and Cellular Physiology and HHMI, Stanford University, Stanford, CA, USA.
Michael SocolichCenter for Physics of Evolving Systems, Biochemistry & Molecular Biology and the Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA.
Margaret A KlurezaDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Robert HenningCenter for Advanced Radiation Sources, University of Chicago, Chicago, IL, USA.
Vukica SrajerCenter for Advanced Radiation Sources, University of Chicago, Chicago, IL, USA.
Rama RanganathanCenter for Physics of Evolving Systems, Biochemistry & Molecular Biology and the Pritzker School for Molecular Engineering, University of Chicago, Chicago, IL, USA; Center for Advanced Radiation Sources, University of Chicago, Chicago, IL, USA. Electronic address: ranganathanr@uchicago.edu.
Doeke R HekstraDepartment of Molecular and Cell Biology and School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. Electronic address: doeke_hekstra@harvard.edu.

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Electric Field-stimulated Protein MechanicsP41GM118217 · NIGMS · UNIVERSITY OF CHICAGO · PI MOFFAT, JOHN KEITH, RANGANATHAN, RAMA · 2019 to 2021
$5.3M
Identifying Principles of Protein Mechanics by Applying Force and Observing MotionDP2GM141000 · NIGMS · HARVARD UNIVERSITY · PI HEKSTRA, DOEKE ROMKE · 2020 to 2020
$2.4M
Seeing Protein Mechanics: The Link Between Molecular Structure, Function, and EvolutionR01GM123456 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RANGANATHAN, RAMA · 2016 to 2020
$2.0M
Data-driven, evolution-based design of proteinsR01GM141697 · NIGMS · UNIVERSITY OF CHICAGO · PI RANGANATHAN, RAMA · 2021 to 2024
$1.3M
NIGMS NIH HHS DP2 GM141000NIGMS NIH HHS P41 GM103393NIGMS NIH HHS P41 GM118217NIGMS NIH HHS R01 GM123456NIGMS NIH HHS R01 GM141697
6 · The paper itself

Abstract

Understanding protein function would be facilitated by direct, real-time observation of chemical kinetics in the atomic structure. The selectivity filter (SF) of the K

Indexed as

PotassiumPotassium ChannelsAnimalsCrystallography, X-RayIon TransportKineticsModels, MolecularProtein ConformationPotassiumPotassium Channelsion channelmembrane proteinpermeationprotein dynamicsstraintime-resolved crystallography

Identifiers

PMID39793560
PMCPMC11924917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.