Evidence map›Paper›PMID 39793039›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

VCP controls KCC2 degradation through FAF1 recruitment and accelerates emergence from anesthesia.

Peng Chen, Jiang-Jian Hu, Yuexin Liu, Boxu Cao, Xue-Jun Song

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng Chen *Department of Medical Neuroscience, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0009-0002-4764-5802
Jiang-Jian Hu *Department of Medical Neuroscience, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0001-6284-5111
Yuexin LiuDepartment of Medical Neuroscience, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0009-0009-7320-2942
Boxu CaoDepartment of Medical Neuroscience, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0009-0004-8268-7973
Xue-Jun SongDepartment of Medical Neuroscience, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0003-4386-9868

Funding

Shenzhen Science and Technology Program KQTD20200820113040070The China Postdoctoral Science Foundation 2023M741538The National Natural Science Foundation of China NSFC82350710225
6 · The paper itself

Abstract

Ubiquitin-proteasomal degradation of K

Indexed as

Adaptor Proteins, Signal TransducingK Cl- CotransportersSymportersValosin Containing ProteinAnesthesiaAnimalsApoptosis Regulatory ProteinsF-Box ProteinsMaleMiceMice, KnockoutPropofolProteasome Endopeptidase ComplexProteolysisUbiquitinUbiquitinationAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsF-Box ProteinsK Cl- CotransportersPropofolProteasome Endopeptidase ComplexSymportersUbiquitinValosin Containing Proteinemergence from anesthesiaFAF1KCC2 degradationVCP

Identifiers

PMID39793039
PMCPMC11725920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.