ArticleProceedings of the National Academy of Sciences of the United States of America2025
Comparing integrative ventilatory and renal acid-base acclimatization in lowlanders and Tibetan highlanders during ascent to 4,300 m.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Hemoglobin mass and plasma volume responses are not different between lowlanders and Tibetan highlanders during early acclimatization to 4300 m.European journal of applied physiology · 2026Article
- Potential pitfalls of using a correction to normative values for the assessment of acid-base compensation during early ascent to high altitude.Experimental physiology · 2026Article
- Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.Experimental physiology · 2026Review
- Mechanisms of ventilatory acclimatization to high altitude.National science review · 2025Article
- Incremental ascent to 4300 m does not alter standing balance in lowlanders or Tibetan highlanders.European journal of applied physiology · 2025Article
- Preacclimatization and base excess rather than deficit?Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reply to Kleinsasser et al.: Superimposed acclimatization and adaptation to low and high altitudes in highlanders compared to lowlanders.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
With over 14 million people living above 3,500 m, the study of acclimatization and adaptation to high altitude in human populations is of increasing importance, where exposure to high altitude (HA) imposes a blood oxygenation and acid-base challenge. A sustained and augmented hypoxic ventilatory response protects oxygenation through ventilatory acclimatization, but elicits hypocapnia and respiratory alkalosis. A subsequent renally mediated compensatory metabolic acidosis corrects pH toward baseline values, with a high degree of interindividual variability. Differential renal compensation between acclimatizing lowlanders (LL) and Tibetan highlanders (TH; Sherpa) with ascent was previously unknown. We assessed ventilatory and renal acclimatization between unacclimatized LL and TH during incremental ascent from 1,400 m to 4,300 m in age- and sex-matched groups of 15-LL (8F) and 14-TH (7F) of confirmed Tibetan ancestry. We compared respiratory and renally mediated blood acid-base acclimatization (PCO
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