Evidence map›Paper›PMID 39793030›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Complex tissue regeneration in

Brennan Riddell, Molly McDonough, Adam Ferguson, John M Kimani, Thomas R Gawriluk, Chi Peng, Stephen G Kiama, Vanessa O Ezenwa, Ashley W Seifert

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. An ear for an ear, but only if you are a deomyinid.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Specific cell states underlie complex tissue regeneration in spiny mice.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Brennan RiddellDepartment of Biology, University of Kentucky, Lexington, KY 40508.
Molly McDonoughDepartment of Biological Sciences, Chicago State University, Chicago, IL 60628.
Adam FergusonGantz Family Collection Center, Field Museum of Natural History, Chicago, IL 60605.
John M KimaniDepartment of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi 00100, Kenya.ORCID 0000-0002-3013-1904
Thomas R GawrilukDepartment of Biology, University of Kentucky, Lexington, KY 40508.
Chi PengDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536.
Stephen G KiamaDepartment of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi 00100, Kenya.
Vanessa O EzenwaDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.ORCID 0000-0002-8078-1913
Ashley W SeifertDepartment of Biology, University of Kentucky, Lexington, KY 40508.ORCID 0000-0001-6576-3664

Funding

Macrophage phenotype orchestrates mammalian tissue regenerationR01AR070313 · NIAMS · UNIVERSITY OF KENTUCKY · PI Ashley Winn Seifert · 2017 to 2026
$3.3M
National Geographic Society (NGS) N/ANIAMS NIH HHS R01 AR070313NSF | OD | Office of International Science and Engineering (ISE) IOS-1353713
6 · The paper itself

Abstract

Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling multiple species among which there is variation in regenerative ability across a phylogenetic framework. Here, we interrogate tissue healing across eleven rodents and show that brush-furred mice (

Indexed as

PhylogenyRegenerationWound HealingAnimalsBiological EvolutionMiceMurinaeRodentiaear pinnaevolutionmammalregenerationrodent

Identifiers

PMID39793030
PMCPMC11725941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.