Evidence map›Paper›PMID 39792668›Full record

ArticleScience advances2025

Cpeb1 remodels cell type-specific translational program to promote fear extinction.

Juan Zhang, Chun-Qing Yang, Zhi-Qiang Liu, Shi-Ping Wu, Zu-Guang Li, Luo-Man Zhang, Hong-Wei Fan, Zi-Yuan Guo, Heng-Ye Man, Xiang Li and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juan ZhangDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0009-0009-3028-911X
Chun-Qing YangDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0009-0000-8770-7348
Zhi-Qiang LiuDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0000-0002-8837-0369
Shi-Ping WuDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Zu-Guang LiDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Luo-Man ZhangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China.ORCID 0009-0006-1081-4974
Hong-Wei FanDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Zi-Yuan GuoCenter for Stem Cell and Organoid Medicine (CuSTOM), Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-2263-0797
Heng-Ye ManDepartment of Biology, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-3530-3066
Xiang LiDepartment of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
You-Ming LuDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0000-0002-2422-5656
Ling-Qiang ZhuDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0000-0001-9964-9229
Dan LiuDepartment of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.ORCID 0000-0001-8078-4674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein translation is crucial for fear extinction, a process vital for adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using a Tet-On 3G genetic approach, we achieved precise temporal control over protein translation in the infralimbic medial prefrontal cortex (

Indexed as

Extinction, PsychologicalFearmRNA Cleavage and Polyadenylation FactorsProtein BiosynthesisAnimalsMaleMiceMicrogliaMicroRNAsNeuronsPrefrontal CortexTranscription FactorsCpeb1 protein, mouseMicroRNAsmRNA Cleavage and Polyadenylation FactorsTranscription Factors

Identifiers

PMID39792668
PMCPMC11721575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.