ArticleJournal of the Chinese Medical Association : JCMA2025
Predictors of the efficacy of CO 2 laser therapy for female stress urinary incontinence.
Article in Journal of the Chinese Medical Association : JCMA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Laser for lower-urinary tract symptoms.Journal of the Chinese Medical Association : JCMA · 2025Article
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3 authors.
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Abstract
backgroundPredictors of the efficacy of a single session of CO 2 laser therapy for female stress urinary incontinence are important for pretreatment consultation. Therefore, this study aimed to evaluate these predictors.
methodsAll consecutive women who underwent vaginal CO 2 laser therapy for stress urinary incontinence were prospectively enrolled in the obstetrics and gynecology department of a medical center from October 2018 to December 2021. Women with a global response assessment (GRA) ≤0 during follow-up were considered to have subjective failure. A multivariable backward stepwise Cox proportional hazard model was used to identify factors influencing subjective failure.
resultsA total of 75 women who underwent single-session vaginal CO 2 laser therapy were evaluated. The median duration of subjective improvement (defined as ≥1 on the GRA) was 18.3 (95% CI, 12.1-18.3 months) months. Multivariable analysis revealed that low voided volume (dL, hazard ratio [HR] = 0.707; area under the curve [AUC] = 0.66, cutoff value of voided volume ≤4.0 dL), high postvoid residual volume (dL, HR = 2.714; AUC = 0.60, cutoff value of postvoid residual volume ≥1.0 dL), and low functional profile length (HR = 0.956; AUC = 0.58, cutoff value of functional profile length ≤2.8 cm) were predictors of subjective failure. Logit(p) was found to predict failure (HR = 1.775; AUC = 0.71, cutoff value of logit(p) ≥0.0). Pad weights decreased at 3- and 6-month follow-up visits (e.g., pad weights: 46.9 ± 62.8 g at baseline, 13.1 ± 29.5 g at 3 months, and 21.0 ± 38.2 g at 6 months, p = 0.006). At 6 months, 8 (21%) women were cured (<1 g pad weight), and 16 (42%) women showed improvement (>50% decrease in pad weight). Overactive bladder symptom improved at 3 and 6 months (ie, Overactive Bladder Symptom Score: 3.2 ± 2.7 at baseline, 2.1 ± 2.2 at 3 months, and 2.0 ± 1.2 at 6 months, p < 0.001). However, no significant change in female sexual function was observed from baseline.
conclusionLow voided volume and high postvoid residual volume are significant predictors of subjective failure following a single session of transvaginal CO2 laser therapy. However, the subjective therapeutic effects appear to diminish over a median duration of 18 months.
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