ArticleScience immunology2025
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis.
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Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
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What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Generation of T cell containing adipose tissue organoids.iScience · 2026Article
- Palmitic acid coordinates impaired visceral adipose ICOShi Treg-mediated immunosuppression and systemic metabolic disturbance during obesity.The Journal of clinical investigation · 2026Article
- Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential.Nature reviews. Immunology · 2026Review
- T Cell Thoughts.Immunological reviews · 2026Review
- The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Dysfunctional adipose tissue-lymphatic crosstalk in obesity.Nature reviews. Endocrinology · 2026Review
- Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026Review
- GPSM1 restricts CD73Nature communications · 2026Article
- Context-dependent roles of sex hormone signaling in controlling visceral adipose tissue Treg heterogeneity and clonal expansion.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Single-cell atlas reveals cellular heterogeneity and BMP5-mediated regulation of adipogenic differentiation in sheep adipose tissue.Communications biology · 2026Article
- Association between metabolic score for visceral fat and adverse outcomes in chronic obstructive pulmonary disease.BMJ open respiratory research · 2026Article
- Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review).International journal of molecular medicine · 2026Review
- Extracellular vesicle-mediated immune-metabolic crosstalk: research advances in inflammatory regulation and the pathogenesis of metabolic diseases.Frontiers in immunology · 2026Review
- Obesity-driven low-grade chronic inflammation as a mechanistic bridge to chronic pain: from adipose tissue remodeling to central sensitization.Frontiers in immunology · 2026Review
- Regulatory T cell therapy in autoimmune and immune-mediated diseases: from basic research to clinical practice and future perspectives.Frontiers in immunology · 2026Review
- Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Immunometabolic Crosstalk in Adipose Tissue Remodeling: Mechanisms and Therapeutic Perspectives.Journal of obesity & metabolic syndrome · 2025Review
- A Lymphatic Perspective on Obesity and Inflammatory Arthritis: New Disease-Modifying Potential in Rheumatology.Journal of clinical medicine · 2025Article
- Lipid Metabolism and Relevance to Chronic Disease.Nutrients · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Cody ElkinsDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9788-5233
Chengyu YeDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0009-0005-4109-6971
Pulavendran SivasamiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Roy MulpurDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7900-7288
Pamela P Diaz-SaldanaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-6630-4328
Amy PengDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0009-0000-3487-2745
Miaoer XuDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Yeun-Po ChiangDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-0054-596X
Samara MollDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Dormarie E Rivera-RodriguezDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-2091-4104
Luisa Cervantes-BarraganDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Tuoqi WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4003-1034
Byron B Au-YeungDivision of Immunology, Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-6446-9102
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7716-8504
Mandy L FordDepartment of Surgery, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-6736-4421
Haydn KissickEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Chaoran LiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-8103-9596
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MImplementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MDeterminants of T Cell Fate in Transplantation ToleranceR01AI164716 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2022 to 2026
$3.6MAntimicrobial Resistance and Therapeutic Discovery Training ProgramT32AI106699 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Joanna B Goldberg · 2014 to 2026
$2.7MRole of dietary fiber-microbiota Interactions in the development and function of small intestinal T cellsR01DK129950 · NIDDK · EMORY UNIVERSITY · PI CERVANTES BARRAGAN, LUISA · 2021 to 2025
$2.4MCytokine and Metabolic Regulation of Adipose-tissue TregsR01DK128061 · NIDDK · EMORY UNIVERSITY · PI LI, CHAORAN · 2021 to 2025
$2.3MT32 Training Program in Cancer BiologyT32CA275777 · NCI · EMORY UNIVERSITY · PI David Sung-wen Yu · 2023 to 2026
$1.1MThe importance of Treg-intrinsic cholesterol metabolism for visceral adipose tissue Treg homeostasis, phenotype, and functionF31DK137590 · NIDDK · EMORY UNIVERSITY · PI ELKINS, CODY · 2023 to 2025
$118kNCATS NIH HHS UL1 TR002378NCI NIH HHS T32 CA275777NIAID NIH HHS R01 AI164716NIAID NIH HHS T32 AI106699NIDDK NIH HHS F31 DK137590NIDDK NIH HHS R01 DK128061NIDDK NIH HHS R01 DK129950NIH HHS P51 OD011132
Abstract
Regulatory T cells (T
Indexed as
CholesterolHomeostasisIntra-Abdominal FatObesityT-Lymphocytes, RegulatoryAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutCholesterol
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.