Evidence map›Paper›PMID 39792612›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair.

Yi Wei, Xiaolin Zhou, Zhenhua Li, Qing Liu, Han Ding, Yunlong Zhou, Ruo-Feng Yin, Lifei Zheng

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Enzyme-Integrated Hydrogels for Advanced Biological Applications.Polymer science & technology (Washington, D.C.) · 2026
    Review
  5. Repurposing of Chemokine Antagonists for Combined Phase-Resolved Spinal Cord Injury Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Review
  8. Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yi WeiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Xiaolin ZhouWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Zhenhua LiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Qing LiuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Han DingWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Yunlong ZhouWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Ruo-Feng YinChina-Japan Union Hospital, Jilin University, Changchun, Jilin, 130031, China.
Lifei ZhengWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.ORCID https://orcid.org/0000-0002-2819-4172

Funding

National Natural Science Foundation of China 22277018National Natural Science Foundation of China 22372049Public Welfare Science and Technology Plan of Wenzhou Y2023120University of Chinese Academy of Sciences WIUCASQD2020015University of Chinese Academy of Sciences WIUCASQD2022006Wenzhou InstituteZhejiang Provincial Natural Science Foundation for Distinguished Young Scholar LR23B030001
6 · The paper itself

Abstract

Protein self-assembly allows for the formation of diverse supramolecular materials from relatively simple building blocks. In this study, a single-component self-assembling hydrogel is developed using the recombinant protein CsgA, and its successful application for spinal cord injury repair is demonstrated. Gelation is achieved by the physical entanglement of CsgA nanofibrils, resulting in a self-supporting hydrogel at low concentrations (≥5 mg mL

Indexed as

HydrogelsSpinal Cord InjuriesAnimalsDisease Models, AnimalNeural Stem CellsRatsRats, Sprague-DawleyRecombinant ProteinsHydrogelsRecombinant ProteinsCsgAhydrogelrecombinant proteinself‐assemblyspinal cord injury repair

Identifiers

PMID39792612
PMCPMC11904991

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.