ArticleJournal of magnetic resonance imaging : JMRI2025
Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.GeroScience · 2026Trial
- Calcific Aortopathy in Response to Aging and Injury.Circulation · 2026Review
- Associations of cardiorespiratory fitness with brain white matter microstructural integrity and white matter hyperintensity volume across the adult lifespan.GeroScience · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Editorial: Midlife brain health: understanding brain aging in middle-age and effects of interventions to prevent neurodegeneration in late life.Frontiers in aging neuroscience · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundCentral arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults, but little is known about this association from an adult lifespan perspective. PURPOSE: To investigate the associations of central arterial stiffness with WM microstructural organization, WM lesion load, cortical thickness, and GM volume in healthy adults across the lifespan. STUDY TYPE: This is a cross-sectional study. SUBJECTS: A total of 173 healthy adults (22-81 years) were included in this study. FIELD STRENGTH/SEQUENCE: 3-T, T1-weighted magnetization prepared rapid gradient echo (MPRAGE), single-shot echo-planar imaging diffusion-weighted, and T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences. ASSESSMENT: The participants underwent measurements of central arterial stiffness using carotid-femoral pulse wave velocity (cfPWV), diffusion tensor imaging (DTI) to measure whole-brain WM microstructural organization with free water (FW) and FW-corrected fractional anisotropy (FA STATISTICAL TESTS: Linear regression models to examine the associations of brain WM and GM measures with age, cfPWV, and age × cfPWV interaction after adjusting for sex, education, and intracranial volume (ICV) (voxel-wise and cluster threshold P < 0.05). To understand the direction of the interaction result, the sample was stratified into lower and higher cfPWV groups using a median split of cfPWV.
resultsAge × cfPWV interactions were observed in WM FW, WMH volume, cortical thickness, and GM volume (P < 0.01) such that the positive regression slopes between age, FW, and WMH volume were higher, while the negative regression slopes between age, cortical thickness, and GM volume were lower in those who had higher cfPWV relative to those who had lower cfPWV. DATA
conclusionCentral arterial stiffening may accelerate the age-related deteriorations in GM and WM structure across the adult lifespan. PLAIN LANGUAGE SUMMARY: Central arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults. We extended this investigation into an adult lifespan perspective by examining the associations of central arterial stiffening with brain structure in adults across age. A total of 172 healthy adults (22-81 years) underwent central arterial stiffening measure using applanation tonometry and brain measurement using MRI. We observed that higher central arterial stiffening may accelerate the age-related deterioration in brain WM and GM structure. These results suggest the importance of maintaining vascular health to slow age-related brain structural changes from an adult lifespan perspective. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY: Stage 5.
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