ArticleAmerican journal of hypertension2025
Nighttime Systolic Blood Pressure a Major Factor of Retinal Vascular Caliber Changes in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.
Article in American journal of hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Changes of retinal microvascular parameters in patients with type 2 diabetes mellitus with or without diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Diabetes Status Modifies the Association Between Carotid Plaque Burden and Retinal Microvascular Parameters.International journal of medical sciences · 2026Article
- Multi-omics integrated analysis identifies causal risk factors and therapeutic targets for diabetic retinopathy.Journal of translational medicine · 2025Article
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Authors and funding
12 authors.
Funding
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Abstract
backgroundChanges in retinal vessel caliber are crucial for detecting early retinopathy, a significant cause of blindness in individuals with Diabetes Mellitus type 2 (T2DM). This study aims to evaluate the changes in retinal vessel caliber and identify factors associated with these changes in recently diagnosed T2DM patients.
methodsThe study included newly diagnosed T2DM patients (within 6 months of diagnosis) who were free of antidiabetic treatment (except metformin) and matched individuals based on age and blood pressure (BP). Data collected included somatometric measurements, BP (office and 24-h), hematological data, albuminuria (via 24-h urine collections), ten-year atherosclerotic cardiovascular disease risk (ASCVD score), endothelial dysfunction (measured by Asymmetric Dimethylarginine, ADMA), retinal microvascular changes, assessed as central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arteriovenous ratio (AVR) using specialized software on nonmydriatic fundus photographs.
resultsThe study involved 87 T2DM patients and 90 controls, aged 57±11 years. Key findings include no significant differences in CRAE, CRVE, and AVR between T2DM patients and controls. Age (P=0.019) and nighttime systolic BP (SBP) (P=0.002) were independent predictors of AVR. CRAE was independently associated with nighttime SBP (P=0.048). CRVE was independently associated with age (P=0.016), dipping (P=0.002), and smoking (P=0.018). In normotensive subjects, AVR was significantly lower in T2DM patients (P=0.035).
conclusionsThe study concludes that increased nighttime SBP is a more critical factor than hyperglycemia in affecting retinal vascular caliber changes in newly diagnosed T2DM patients. This highlights the importance of managing nocturnal hypertension to prevent retinal damage in this patient population.
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