ArticleSurgical endoscopy2025
The efficacy and safety of submucosal tunneling endoscopic resection in treating large esophageal subepithelial lesions.
Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Closure strategies post-EMR for esophageal SMTs.Surgical endoscopy · 2026Article
- Third-space endoscopy: Current techniques, clinical applications, and future directions.The Journal of international medical research · 2026Review
- Submucosal tunneling endoscopic resection in challenging esophageal subepithelial lesions: a minimally invasive approach.iGIE : innovation, investigation and insights · 2026Article
- Submucosal tunneling endoscopic resection to treat a large symptomatic esophageal lipoma.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2026Article
- Peroral endoscopic tumor resection of a large esophageal leiomyoma using refined traction and extraction techniques.Endoscopy · 2026Article
- Submucosal Tunneling Endoscopic Resection for Upper Gastrointestinal Subepithelial Lesions: Development of a Digital Nomogram.Endoscopy international open · 2026Article
- Endoscopic resection in treatment of intramural esophageal cysts: Retrospective analysis of 67 cases.Endoscopy international open · 2026Article
- Feasibility and safety of endoscopic resection for cardial submucosal tumors more than 30 mm in diameter.Surgical endoscopy · 2025Article
- Performance of endoscopic submucosal dissection and submucosal tunneling endoscopic resection for esophageal submucosal tumors: A multicenter retrospective cohort study.Annals of gastroenterologyArticle
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8 authors.
Funding
Abstract
backgroundSubmucosal tunneling endoscopic resection (STER) is considered an effective, safe and minimally invasive treatment for esophageal subepithelial lesions (SELs) with maximal dilameter less than 3.0 cm, yet its efficacy for lesions over 3.0 cm remains unclear. This study aimed to evaluate the application value of STER for SELs of varying sizes.
methodsConsecutive patients with esophageal SELs who underwent STER were retrospectively enrolled from May 2017 to March 2024. Baseline characteristics, surgical information and prognosis were collected and compared among patients with SELs of different sizes, as defined by the maximal diameter of the postoperative specimen.
resultsA total of 133 patients were included, among whom 69 with SELs < 3.0 cm, 31 with SELs between 3.0 and 5.0 cm, 33 with SELs ≥ 5.0 cm. 1 case with SELs ≥ 5.0 cm was converted to endoscopic submucosal dissection (ESD) due to the tumor's adhesion to the epithelial layer. Among those who completed the STER procedure, the en bloc resection rate was 100.0% for all three subgroups, and the recurrence and metastasis rates were 0.0%, demonstrating that STER is effective for SELs of all sizes. However, SELs ≥ 5.0 cm were associated with more adverse events, a higher number of difficult procedures, and more frequent intensive care unit (ICU) transfers (all p < 0.050).
conclusionsSTER is effective and safe for treating esophageal SELs. For lesions exceeding 5 cm, while still feasible, the procedure requires meticulous planning, advanced techniques and careful monitoring due to increased complexity and risks.
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