SynthesisArchives of dermatological research2025
A comprehensive systemic review and meta-analysis of the association between lipid profile and hidradenitis suppurativa.
Synthesis in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Decreased HDL-C in hidradenitis suppurativa: association with systemic inflammatory phenotype and implications for risk stratification.Lipids in health and disease · 2026Article
- Efficacy of Secukinumab in Chinese Patients with Moderate-to-Severe Hidradenitis Suppurativa: A 16-Week, Single-Center, Prospective, Real-World Study.Journal of inflammation research · 2026Article
- Oxidative Stress, High Density Lipoproteins and Hidradenitis Suppurativa: A Prospective Study.Antioxidants (Basel, Switzerland) · 2025Article
- Clinical and laboratory characteristics of hidradenitis suppurativa in a Chinese cohort: a retrospective analysis of 197 cases.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile several studies have suggested a connection between Metabolic Syndrome (MetS) and Hidradenitis Suppurativa (HS), a definitive analysis confirming the association between lipid abnormalities and HS based on actual lipid values is lacking. Previous research, using odds ratios from ICD codes, indicates links between elevated triglycerides and low high-density lipoprotein levels with HS. However, these findings may not fully represent real-life situations, as no comprehensive analysis using actual lipid measurements has been performed.
objectivesTo examine the relationship between lipid profile values-total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)-and HS.
methodsA comprehensive search of PubMed, Cochrane Library, and Embase was conducted to identify studies reporting lipid profiles in HS patients. A meta-analysis using standardized mean differences (SMDs) was performed to assess the association between lipid abnormalities and HS.
resultsThe meta-analysis found that HS patients had significantly higher TG levels (SMD = 0.28, 95% CI: 0.09-0.47, P = 0.004) and lower HDL levels (95% CI: -0.53 to -0.16, P < 0.001) compared to healthy controls. No significant differences were observed in total cholesterol (SMD = 0.01, 95% CI: -0.19-0.21, P = 0.93) and LDL levels (SMD = 0.04, 95% CI: -0.10-0.17, P = 0.61). These results corroborate earlier studies linking HS with dyslipidemia, particularly hypertriglyceridemia and hypo-HDL cholesterolemia, with the added strength of using actual lipid values.
conclusionsThis study confirms the association between hypertriglyceridemia and low HDL cholesterol in HS patients, highlighting the broader systemic association of the condition. Dermatologists should monitor lipid profiles in HS patients to mitigate potential cardiovascular risks through early detection and management.
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