ArticleInvestigative ophthalmology & visual science2025
Retinal Sensitivity in KCNV2-Associated Retinopathy.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Retinal Sensitivity Loss and Beyond inTurkish journal of ophthalmology · 2025Article
- Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation.Translational vision science & technology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Purpose: The purpose of this study was to analyze the retinal sensitivity under photopic, mesopic, and scotopic conditions in a cohort of patients affected with KCNV2-associated retinopathy. Methods: Cross-sectional evaluation of molecularly confirmed individuals was conducted. Data were obtained prospectively. The main microperimetry parameters analyzed were mean sensitivity (MS) and number of floor effects (noF) in the central macular zone (CMZ; central 6 degrees) and peripheral macular zone (PMZ; 6 to 10 degrees). Interocular symmetry was also assessed. Results: The MS under photopic, mesopic, and scotopic conditions were, respectively, 20.2 (6.3-29.5, ±6.5), 16.2 (3.7-23.1, ±5.3), and 1.3 (0-13.3, ±3.8) in the right eyes, and 21.1 (9.8-28.9, ±6.1), 16.8 (9.6-23.5, ±4.0), and 1.1 (0-12.4, ±3.5) in the left eyes. MS was highly symmetric between eyes (Pearson correlation coefficient) in photopic (r = 0.96, P < 0.0001), mesopic (r = 0.9, P < 0.0001), and scotopic (r = 0.98, P < 0.0001) testing conditions. MS was also highly symmetric (Pearson coefficient) in the photopic CMZ (r = 0.97, P = 0.0001) and PMZ (r = 0.95, P = 0.0002), mesopic CMZ (r = 0.94, P = 0.0003), and PMZ (r = 0.92, P = 0.0009), and scotopic CMZ (r = 0.99, P < 0.0001) and PMZ (r = 0.99, P < 0.0001).The mean noF (± standard deviation [SD]; range) was 4.6 (SD = ±5.3, range = 0-16) in photopic, 5.0 (SD = ±5.4, range = 0-15) in mesopic, and 23.2 (SD = ±8.6, range = 0-28) in scotopic conditions. Subject 01-041 was the only affected individual in which no floor effect was found. Simple linear regression revealed a significant inverse relationship between age and MS, and a direct relationship between age and noF. Conclusions: KCNV2-associated retinopathy is a largely symmetric disease from a functional perspective. Despite the early decrease in scotopic retinal sensitivity, our data suggests a large window for photoreceptor rescue with novel treatments, such as gene therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.