ArticleVeterinary medicine and science2025
Comparison of Freestyle Optium Neo H and Centrivet GK Device in the Diagnosis of Hypoglycaemia and Hyperketonaemia in Dairy Goats: A Field Study.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Double burden: microfilariae infection amplifies metabolic costs of moult in breeding male village weavers (Biochemistry and biophysics reports · 2026Article
- Comparative Evaluation of Different Blood Collection Sites for the Assessment of Beta-Hydroxybutyric Acid Concentrations Using a Handheld Meter in Sheep.Veterinary medicine and science · 2025Article
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Abstract
backgroundThere is a lack of data on the validation and diagnostic performance of the Freestyle Optium Neo-H (Freestyle) and Centrivet GK (Centrivet) devices for the diagnosis of hypoglycaemia, hyperglycaemia and hyperketonaemia in goats.
objectivesThe aim of the present study was to validate the Freestyle and Centrivet for the analysis of whole blood beta-hydroxybutyric acid (BHBA) and to validate the Freestyle for the analysis of whole blood glucose concentrations using the reference method (RM) in goat blood collected from the jugular and ear veins.
methodsVenous blood samples were utilised to assess glucose and BHBA concentrations using the Freestyle, Centrivet and RM. The cut-off point of BHBA was ≥ 0.8 mmol/L for hyperketonaemia. A total of 198 paired blood samples (vena jugularis and ear vein) were collected from 99 hair goats. The cut-off point for hypoglycaemia diagnosis was < 49 mg/dL.
resultsThere were proportional but no constant errors between RM and Freestyle and Centrivet for BHBA, and both proportional and constant errors were observed for glucose analysis. The mean bias for BHBA analysis was 0.14 and 0.06 mmol/L (Freestyle-RM) 0.51 and 0.16 mmol/L (Centrivet-RM) for jugular and ear veins, respectively. The mean bias for blood glucose analysis was 0.0 and 5.6 mg/L between Freestyle and RM in the jugular and ear veins, respectively. The sensitivity (Centrivet: 50%-61.3%; Freestyle: 93.6%-75.8%) and specificity (Centrivet GK: 75.7%-73%; Freestyle: 37.8%-70.3%) were determined in jugular and ear vein blood for hyperketonaemia diagnostics, respectively. The AUC of Freestyle was 0.89 and 0.95 in the jugular and ear vein for hypoglycaemia, respectively. The sensitivity of Freestyle was 60.3% and 96.8% in the jugular and ear vein for hypoglycaemia. The specificity of Freestyle was 100.0% and 76.7% for hypoglycaemia in jugular and ear veins, respectively.
conclusionsFreestyle demonstrated acceptable diagnostic performance for hypoglycaemia in ear veins, but neither Freestyle nor Centrivet showed sufficient diagnostic performance for hyperketonaemia. Both analysers were not interchangeable with RM in BHBA and glucose analysis.
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