Inverted Pyramid Nanostructures Coupled with a Sandwich Immunoassay for SERS Biomarker Detection.

Wen-Huei Chang, Shao-Quan Zhang, Zi-Yi Yang, Chun-Hung Lin

Abstract read

In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hydrophobic and Sticky Silver-Decorated Nanoimprinted ZnO Nanograss Substrates for Enhanced SERS Performance.ACS applied materials & interfaces · 2025
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wen-Huei ChangDepartment of Applied Chemistry, National Pingtung University, Pingtung 90003, Taiwan.ORCID 0000-0003-3235-9918

Shao-Quan ZhangDepartment of Photonics, National Cheng Kung University, Tainan 70101, Taiwan.

Zi-Yi YangDepartment of Photonics, National Cheng Kung University, Tainan 70101, Taiwan.

Chun-Hung LinDepartment of Photonics, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0001-6400-9969

Funding

National Science and Technology Council, Taiwan MOST 109-2635-H-153-001-, MOST 109-2221-E-006 -206 -, MOST 110-2221-E-006-159-, NSTC 112-2221-E-006 -167-MY3, and NSTC 113-2221-E-153 -001 -.

6 · The paper itself

Abstract

Cancer diagnostics often faces challenges, such as invasiveness, high costs, and limited sensitivity for early detection, emphasizing the need for improved approaches. We present a surface-enhanced Raman scattering (SERS)-based platform leveraging inverted pyramid SU-8 nanostructured substrates fabricated via nanoimprint lithography. These substrates, characterized by sharp apices and edges, are further functionalized with (3-aminopropyl)triethoxysilane (APTES), enabling the uniform self-assembly of AuNPs to create a highly favorable configuration for enhanced SERS analysis. Performance testing of the substrates using malachite green (MG) as a model analyte demonstrated excellent detection capabilities, achieving a limit of detection as low as 10

Indexed as

4-mercaptobenzoic acidbiomarker detectionhyaluronic acidimmunoassayinverted pyramidmalachite greensurface-enhanced Raman scattering (SERS)

Identifiers

PMID39791822

DOI10.3390/nano15010064

PMCPMC11722957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.