Evidence map›Paper›PMID 39791736›Full record

ArticleCells2025

Dysregulation of the NLRP3 Inflammasome and Promotion of Disease by IL-1β in a Murine Model of Sandhoff Disease.

Nick Platt, Dawn Shepherd, David A Smith, Claire Smith, Kerri-Lee Wallom, Raashid Luqmani, Grant C Churchill, Antony Galione, Frances M Platt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nick PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Dawn ShepherdDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
David A SmithDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.ORCID 0000-0002-9845-5913
Claire SmithDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Kerri-Lee WallomDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.ORCID 0000-0002-2842-1275
Raashid LuqmaniNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford OX3 7LD, UK.
Grant C ChurchillDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Antony GalioneDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Frances M PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.ORCID 0000-0001-7614-0403

Funding

National Tay-Sachs ad Allied Diseases 1234Wellcome Trust 203834/Z/16/Z
6 · The paper itself

Abstract

Sandhoff disease (SD) is a progressive neurodegenerative lysosomal storage disorder characterized by GM2 ganglioside accumulation as a result of mutations in the

Indexed as

Disease Models, AnimalInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinSandhoff DiseaseAdenosine TriphosphateAnimalsLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMice, KnockoutAdenosine TriphosphateInflammasomesInterleukin-1betaLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseGM2 gangliosidosisIL-1βinflammationlysosomal storage diseaseNLRP3 inflammasomeSandhoff disease

Identifiers

PMID39791736
PMCPMC11720672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.