Evidence map›Paper›PMID 39791533›Full record

ReviewEuropean heart journal2025

Coronary atherosclerosis in athletes: emerging concepts and preventive strategies.

Guido Claessen, Thijs M H Eijsvogels, Christine M Albert, Aaron L Baggish, Benjamin D Levine, Eloi Marijon, Erin D Michos, Andre La Gerche

Abstract readReview
In one paragraph

Review in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Early atherogenesis: In search of etiology.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Precision Cardiogenomics in Athletes.International journal of molecular sciences · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guido ClaessenFaculty of Medicine and Life Sciences, Biomedical Research Institute, LCRC, UHasselt, Hasselt, Belgium.ORCID 0000-0001-8261-6666
Thijs M H EijsvogelsDepartment of Medical Biosciences, Exercise Physiology Research Group, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0003-0747-4471
Christine M AlbertDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aaron L BaggishDivision of Cardiology, Lausanne University Hospital, Lausanne, Vaud, Switzerland.
Benjamin D LevineDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Eloi MarijonParis Cardiovascular Research Center, Université Paris Cité, Inserm U970, Paris, France.
Erin D MichosDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andre La GercheHeart, Exercise and Research Trials (HEART) Lab, St. Vincent's Institute of Medical Research, Melbourne, Australia.ORCID 0000-0002-3906-3784

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There should be no assumption that an athlete is immune to coronary artery disease (CAD), even when traditional cardiovascular (CV) risk factors appear well-managed. Excelling in certain aspects of health does not equate to total CV protection. Recent data from cardiac imaging studies have raised the possibility that long-term, high-volume, high-intensity endurance exercise is associated with coronary atherosclerosis. Whilst the risk of CV events has not been shown to rise with athletic activity, the potential for CAD should not be overlooked as it is the leading cause of sudden cardiac death in athletes >35 years of age (i.e. 'Masters athletes'). Evaluating both traditional and non-traditional risk factors for CAD is the most important part of pre-participation evaluation in Masters athletes. When managing athletes at risk of CAD it is important to adopt a shared decision-making approach regarding lifestyle adaptation and lipid-lowering treatments. In the great majority of athletes, after excluding the presence of symptoms and inducible ischaemia, this advice should include encouragement to continue exercising as available data indicate that higher levels of fitness are associated with a markedly attenuated incidence of coronary events regardless of the severity of coronary disease. Future research is needed to establish the relationship between clinically relevant CAD outcomes and coronary artery calcification in Masters Athletes, the role of sex, as well as exploration of the mechanisms underpinning these unexpected CV adaptations.

Indexed as

AthletesCoronary Artery DiseaseDeath, Sudden, CardiacExerciseHeart Disease Risk FactorsHumansRisk FactorsAthletesCardiovascular riskCoronary atherosclerosisCoronary computed tomography angiographyExerciseIschaemic heart diseaseSudden cardiac death

Identifiers

PMID39791533
PMCPMC11887545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.